Condensed Consolidated Statements of Operations and Comprehensive Loss - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021	Sep. 30, 2022	Sep. 30, 2021
Income Statement [Abstract]
Total revenue	$ 1,739	$ 1,440	$ 4,821	$ 4,666
Operating costs and expenses:
Cost of goods sold	184	131	670	466
Research and development	81,553	83,497	236,868	207,723
Selling, general and administrative	61,482	48,706	160,370	131,899
Total operating costs and expenses	143,219	132,334	397,908	340,088
Loss from operations	(141,480)	(130,894)	(393,087)	(335,422)
Interest income, net	4,127	692	7,397	2,132
Other income, net	30	31	52	110
Net loss	$ (137,323)	$ (130,171)	$ (385,638)	$ (333,180)
Net loss per share—basic	$ (2.31)	$ (2.21)	$ (6.51)	$ (5.69)
Net loss per share—diluted	$ (2.31)	$ (2.21)	$ (6.51)	$ (5.69)
Weighted average number of common shares outstanding— basic	59,428,123	58,819,548	59,242,563	58,593,743
Weighted average number of common shares outstanding— diluted	59,428,123	58,819,548	59,242,563	58,593,743
Comprehensive loss:
Net loss	$ (137,323)	$ (130,171)	$ (385,638)	$ (333,180)
Other comprehensive items:
Unrealized loss on marketable securities	(1,011)	(21)	(12,223)	(721)
Total other comprehensive loss	(1,011)	(21)	(12,223)	(721)
Total comprehensive loss	$ (138,334)	$ (130,192)	$ (397,861)	$ (333,901)