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Stock-Based Compensation - Additional Information (Detail)
3 Months Ended 9 Months Ended 12 Months Ended
Jun. 16, 2022
shares
Jan. 01, 2022
shares
Sep. 30, 2022
USD ($)
shares
Jun. 30, 2022
USD ($)
shares
Mar. 31, 2022
shares
Dec. 31, 2021
shares
Sep. 30, 2021
USD ($)
shares
Jun. 30, 2021
USD ($)
shares
Mar. 31, 2021
USD ($)
shares
Jun. 30, 2020
shares
Sep. 30, 2022
USD ($)
Milestone
$ / shares
shares
Sep. 30, 2021
USD ($)
Milestone
$ / shares
shares
Dec. 31, 2021
shares
Dec. 31, 2020
Sep. 20, 2018
shares
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                              
Share based compensation granted under plan vested period                     4 years        
Share based compensation, vest period                     1 year        
Share based compensation, term of plan                     10 years        
Total number of shares outstanding     9,088,581               9,088,581        
Common stock available for issuance under stock option plan     7,223,536               7,223,536        
Issuance of common stock under the employee stock purchase plan, Shares 300,000                            
Stock-based compensation expense | $     $ 13,169,000       $ 34,342,000       $ 46,358,000 $ 83,981,000      
Weighted average grant date fair value per share | $ / shares                     $ 25.96 $ 53.42      
Time Based Restricted Stock Units [Member]                              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                              
Share based compensation granted under plan vested period           4 years       2 years          
Share based compensation remaining vesting period           3 years                  
Share based compensation vesting frequency           quarterly                  
Restricted stock units granted           268,119       550,890 0 0      
Restricted stock units vested     59,950 291,505 0   0 113,941 0            
Fair value of restricted stock units vested | $     $ 2,300,000 $ 9,500,000       $ 8,800,000              
Outstanding and unvested restricted stock units     179,676               179,676        
Total unrecognized stock-based compensation expense | $     $ 5,500,000               $ 5,500,000        
Performance Restricted Stock Units [Member]                              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                              
Outstanding and unvested restricted stock units     1,209,581               1,209,581        
Total unrecognized stock-based compensation expense | $     $ 69,500,000               $ 69,500,000        
Stock Options [Member]                              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                              
Options granted                     1,008,027        
Total number of shares outstanding     7,699,324     7,283,439         7,699,324   7,283,439    
Stock-based compensation expense | $     $ 11,992,000       $ 19,516,000       $ 40,659,000 $ 60,740,000      
Total unrecognized stock-based compensation expense | $     70,500,000               $ 70,500,000        
Weighted average period of unrecognized compensation costs                     2 years 8 months 23 days        
Intrinsic value of options exercised | $                     $ 4,400,000 8,000,000.0      
Performance-Based Stock Options [Member]                              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                              
Stock-based compensation expense | $                     $ 0 $ 0      
Milestones achieved | Milestone                     0 0      
Performance Shares [Member]                              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                              
Options granted             0 0     0        
Total unrecognized stock-based compensation expense | $     $ 11,800,000               $ 11,800,000        
Number of shares outstanding and unvested stock options     681,451               681,451        
Performance Shares [Member] | Chief Executive Officer [Member]                              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                              
Options granted                 650,000            
Restricted Stock Units [Member]                              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                              
Restricted stock units granted                     569,410        
Stock-based compensation expense | $     $ 730,000       $ 14,563,000       $ 4,982,000 $ 22,538,000      
Outstanding and unvested restricted stock units     1,389,257     1,256,098         1,389,257   1,256,098    
Restricted Stock Units Vest One Year Anniversary [Member]                              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                              
Restricted stock units vesting percentage                     25.00%        
Restricted Stock Units Vest One Year Anniversary [Member] | Time Based Restricted Stock Units [Member]                              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                              
Restricted stock units vesting percentage           25.00%       25.00%          
Restricted stock units vesting period month and year           2022-09       2021-04          
Share-Based Payment Arrangement, Tranche Two | Time Based Restricted Stock Units [Member]                              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                              
Restricted stock units vesting percentage           75.00%       75.00%          
Restricted stock units vesting period month and year                   2022-04          
2011 Plan [Member]                              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                              
Options granted                     0        
2014 Plan [Member]                              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                              
Common stock shares annual increase added to plan   2,357,482                          
2014 Plan [Member] | Performance Restricted Stock Units [Member]                              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                              
Restricted stock units granted     57,480       47,040       569,410 420,161      
Fair value of restricted stock units vested | $             $ 0 $ 6,100,000 $ 0   $ 0        
Milestone performance restricted stock percentage                           39  
Stock-based compensation expense | $             $ 12,600,000       $ 0        
2014 Plan [Member] | Maximum [Member]                              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                              
Percentage of increase on outstanding shares of Common stock                         4.00%    
2016 Plan [Member]                              
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                              
Total number of shares reserved for issuance                             1,200,000