Net Loss Per Share (Tables)

9 Months Ended

Sep. 30, 2022

Earnings Per Share [Abstract]

Summary of Basic and Diluted Net Loss Per Share

The following table shows the calculation of basic and diluted net loss per share for the three and nine months ended September 30, 2022 and 2021:

	Three Months Ended September 30,						Nine Months Ended September 30,
	2022			2021			2022			2021
Basic net loss per share:
Numerator:
Net loss (in thousands)	$	(137,323	)	$	(130,171	)	$	(385,638	)	$	(333,180	)
Denominator:
Weighted average common stock    outstanding—basic		59,428,123			58,819,548			59,242,563			58,593,743
Dilutive effect of shares of common    stock equivalents resulting from    common stock options and restricted    stock units		—			—			—			—
Weighted average common stock    outstanding—diluted		59,428,123			58,819,548			59,242,563			58,593,743
Net loss per share—basic and diluted	$	(2.31	)	$	(2.21	)	$	(6.51	)	$	(5.69	)

Summary of Anti-Dilutive Common Stock Equivalents Outstanding

The following table summarizes common stock equivalents outstanding that were excluded from the calculation of diluted net loss per share because including them would have been anti-dilutive as of September 30, 2022 and 2021:

	Three Months Ended September 30,				Nine Months Ended September 30,
	2022		2021		2022		2021
Stock options		7,017,873		6,728,998		7,017,873		6,728,998
Restricted stock units		179,676		310,418		179,676		310,418
Employee stock purchase plan		43,877		15,437		43,877		15,437
		7,241,426		7,054,853		7,241,426		7,054,853