Income Taxes (Tables)

12 Months Ended

Dec. 31, 2022

Income Tax Disclosure [Abstract]

Schedule of Reconciliation of Differences Between Federal Income Tax Rate and Effective Tax Rate

The following reconciles the differences between income taxes computed at the federal income tax rate and the provision for income taxes:

	Year Ended December 31,
	2022		2021		2020
Expected income tax benefit at the federal statutory rate	21.0	%	21.0	%	21.0	%
State taxes, net of federal benefit	0.0		0.0		0.0
Change in federal statutory rate	0.0		0.0		0.0
Non-deductible stock compensation	(4.5)		(3.1)		0.2
True-up federal deferred taxes	7.7		0.0		0.0
Non-deductible items and other	0.5		(1.7)		(3.6)
Federal and state credits	1.0		0.7		0.5
Change in valuation allowance	(25.7)		(16.9)		(18.1)
Total	0.0	%	0.0	%	0.0	%

Schedule of Deferred Tax Assets

The principal components of the Company’s net deferred tax assets consisted of the following at December 31, 2022 and 2021 (in thousands):

	Year Ended December 31,
	2022		2021
Deferred tax assets
Net operating loss carryforwards	$	155,153	$	140,581
Research and development tax credits	10,406		9,149
Reserves and accruals	7,091		6,004
Operating lease liability	1,868		2,615
Capitalized §174 Costs	4,476		—
Share-based compensation	8,157		1,406
Other	5,277		4,109
Total deferred tax assets	192,428		163,864
Less: Valuation allowance	(191,051)		(161,487)
Net deferred tax assets	1,377		2,377
Deferred tax liabilities
Right-of-use assets	(1,377)		(2,377)
Total deferred tax liabilities	(1,377)		(2,377)
Net deferred tax assets	$	—	$	—

Schedule of Unrecognized Tax Benefits

At December 31, 2022 and 2021, the Company’s unrecognized tax benefits consist of the following (in thousands):

	Year Ended December 31,
	2022		2021
Unrecognized tax benefit, beginning of period	$	3,357	$	2,681
Gross increases — current year tax positions	908		704
Gross increases — prior year tax positions	—		—
Gross decreases — prior year tax positions	(363)		(28)
Unrecognized tax benefit, end of period	$	3,902	$	3,357