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Background and Organization - Additional Information (Detail) - USD ($)
$ in Thousands
3 Months Ended 9 Months Ended
Sep. 30, 2018
Sep. 30, 2017
Sep. 30, 2018
Sep. 30, 2017
Dec. 31, 2017
Organization Consolidation And Presentation Of Financial Statements [Abstract]          
Net loss $ (32,852) $ (11,216) $ (59,656) $ (47,530)  
Net cash used from operations     (77,429) $ (43,694)  
Cash and cash equivalents $ 201,543   $ 201,543   $ 57,389