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Debt - Scheduled Future Payments on Term Loan (Detail) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Debt Instrument [Line Items]    
Long-term portion $ 44,290 $ 29,016
CRG Term Loan    
Debt Instrument [Line Items]    
2017 3,926  
2018 17,793  
2019 29,082  
2020 16,897  
Total future payments 67,698  
Less: amount representing interest and end-of-term facility fee (22,698)  
Total principal amount 45,000  
Less: unamortized debt discount (710)  
Carrying value of long-term debt 44,290  
Less: current portion 0  
Long-term portion $ 44,290