Income Taxes (Tables)

12 Months Ended

Dec. 31, 2015

Income Tax Disclosure [Abstract]

Schedule of Reconciliation of Differences Between Income Taxes

The following reconciles the differences between income taxes computed at the federal income tax rate and the provision for income taxes:

	Year Ended December 31,
	2015				2014				2013
Expected income tax benefit at the federal statutory rate	34.0			%		34.0		%		34.0		%
State taxes, net of federal benefit		(0.8	)			3.7				1.5
Change in effective tax rate		(0.9	)			1.3				0.0
Non-deductible items and other		(0.5	)			0.4				(2.1	)
Federal and state credits		(0.7	)			1.2				2.0
Change in valuation allowance		(31.10	)			(40.60	)			(35.40	)
Total		0.0		%		0.0		%		0.0		%

Schedule of Deferred Tax Assets

The principal components of the Company’s net deferred tax assets consisted of the following at December 31, 2015 and 2014 (in thousands):

	Year Ended December 31,
	2015			2014
Net operating loss carryforwards	$	60,979		$	46,024
Research and development tax credits		1,731			2,441
Reserves and accruals		966			724
Other		2,433			2,948
Total deferred tax assets		66,109			52,137
Valuation allowance		(66,109	)		(52,137	)
Net deferred tax assets	$	—		$	—

Schedule of Unrecognized Tax Benefits

At December 31, 2015 and 2014, the Company’s unrecognized tax benefits consist of the following:

	Year Ended December 31,
	2015		2014
Unrecognized tax benefit, beginning of period	$	—	$	—
Gross increases — current year tax positions		130		—
Gross decreases — current year tax positions		—		—
Gross increases — prior year tax positions		612		—
Unrecognized tax benefit, end of period	$	742	$	—