144/A 0001966249-24-000017 0001638474 XXXXXXXX LIVE 0001597264 Blueprint Medicines Corp 001-37359 45 Sidney Street Cambridge MA 02139 617-374-7580 Albers Jeffrey W. Director Common Citigroup Global Markets Inc.

388 Greenwich Street New York NY 10013

5000 510000.00 6114723 11/07/2024 NASDAQ COMMON 02/16/2017 Grant of vested options Issuer N 5000 02/16/2021 Compensation for services N Albers, Jeffrey W.

c/o Blueprint Medicines Corp. 45 Sydney Street Cambridge MA 02139

Common 09/09/2024 19702 1685911.00 Amended to correct acquisition details concerning the shares sold hereunder. 11/12/2024 05/08/2024 /s/ Aegis J. Frumento as a duly authorized representative of Citigroup Global Markets Inc., as attorney-in-fact for JEFFREY W. ALBERS