Stock-based Compensation - Stock-based Compensation Expense - By Classification (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021	Sep. 30, 2022	Sep. 30, 2021
Total stock based compensation expense
Stock-based compensation expense	$ 24,109	$ 23,958	$ 72,855	$ 68,949
Research and Development
Total stock based compensation expense
Stock-based compensation expense	10,010	10,250	30,548	29,682
General and Administrative Expense
Total stock based compensation expense
Stock-based compensation expense	$ 14,099	$ 13,708	$ 42,307	$ 39,267