Stock-based Compensation - Stock Options - Activity (Details)	9 Months Ended
	Sep. 30, 2022 $ / shares shares
Shares
Outstanding at beginning of period (in shares) | shares	5,682,022
Granted (in shares) | shares	1,126,919
Exercised (in shares) | shares	(206,582)
Cancelled (in shares) | shares	(286,619)
Outstanding at end of period (in shares) | shares	6,315,740
Weighted-Average Exercise Price
Outstanding at beginning of period (in dollars per share) | $ / shares	$ 69.37
Granted (in dollars per share) | $ / shares	60.97
Exercised (in dollars per share) | $ / shares	18.70
Cancelled (in dollars per share) | $ / shares	79.26
Outstanding at end of period (in dollars per share) | $ / shares	$ 69.07
Additional disclosures
Shares - Exercisable (in shares) | shares	4,028,524
Weighted-Average Exercise Price - Exercisable (in dollars per share) | $ / shares	$ 66.34