Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021
Cash flows from operating activities
Net loss	$ (398,871)	$ (325,399)
Adjustments to reconcile net income (loss) to net cash provided by (used in) operating activities:
Depreciation and amortization	4,719	4,816
Non-cash lease expense	6,212	4,668
Stock-based compensation	72,855	68,949
Non-cash interest expense	8,389
Non-cash customer consideration	(27,500)
Other	787	2,677
Changes in assets and liabilities:
Accounts receivable	5,553	(11,375)
Unbilled accounts receivable	9,282	6,891
Inventory	(20,653)	(11,812)
Prepaid expenses and other current assets	(15,575)	(1,795)
Other assets	(11,886)	(2,842)
Accounts payable	(2,031)	5,144
Accrued expenses	7,833	(12,844)
Other long-term liabilities	5,730
Deferred revenue	(19,952)	(5,761)
Operating lease liabilities	(5,764)	(5,856)
Net cash used in operating activities	(380,872)	(284,539)
Cash flows from investing activities
Purchases of property and equipment	(7,438)	(1,831)
Purchases of investments	(258,654)	(514,906)
Maturities of investments	170,123	637,831
Other	(289)
Net cash provided by (used in) investing activities	(96,258)	121,094
Cash flows from financing activities
Net proceeds from the sale of future royalties and revenues	415,836
Net proceeds from term loan facility	137,797
Net proceeds from stock option exercises and employee stock purchase plan	5,686	32,787
Net cash provided by financing activities	559,319	32,787
Net increase (decrease) in cash, cash equivalents, and restricted cash	82,189	(130,658)
Cash, cash equivalents and restricted cash at beginning of period	215,119	689,804
Effect of exchange rate changes on cash, cash equivalents and restricted cash	(685)	(382)
Cash, cash equivalents and restricted cash at end of period	296,623	558,764
Supplemental cash flow information
Cash paid for interest	2,956
Property and equipment purchases unpaid at period end	195	206
Cash paid for taxes, net	$ 4,018	$ 674