Condensed Consolidated Statements of Stockholders' Equity - USD ($) $ in Thousands	Common Stock	Additional Paid-In Capital	Accumulated Other Comprehensive Loss	Accumulated Deficit	Total
Beginning Balance at Dec. 31, 2020	$ 58	$ 2,106,600	$ (5,214)	$ (631,356)	$ 1,470,088
Beginning Balance (in shares) at Dec. 31, 2020	57,793,533
Increase (Decrease) in Stockholders' Equity
Issuance of common stock under stock plan		8,318			8,318
Issuance of common stock under stock plan (in shares)	483,879
Stock-based compensation expense		21,212			21,212
Other comprehensive income (loss)			117		117
Net loss				(99,714)	(99,714)
Ending Balance at Mar. 31, 2021	$ 58	2,136,130	(5,097)	(731,070)	1,400,021
Ending Balance (in shares) at Mar. 31, 2021	58,277,412
Beginning Balance at Dec. 31, 2020	$ 58	2,106,600	(5,214)	(631,356)	1,470,088
Beginning Balance (in shares) at Dec. 31, 2020	57,793,533
Increase (Decrease) in Stockholders' Equity
Net loss					(325,399)
Ending Balance at Sep. 30, 2021	$ 59	2,209,456	(5,673)	(956,755)	1,247,087
Ending Balance (in shares) at Sep. 30, 2021	58,814,666
Beginning Balance at Mar. 31, 2021	$ 58	2,136,130	(5,097)	(731,070)	1,400,021
Beginning Balance (in shares) at Mar. 31, 2021	58,277,412
Increase (Decrease) in Stockholders' Equity
Issuance of common stock under stock plan	$ 1	11,709			11,710
Issuance of common stock under stock plan (in shares)	254,823
Purchase of common stock under ESPP		1,733			1,733
Purchase of common stock under ESPP (in shares)	22,324
Stock-based compensation expense		24,522			24,522
Other comprehensive income (loss)			(738)		(738)
Net loss				(108,444)	(108,444)
Ending Balance at Jun. 30, 2021	$ 59	2,174,094	(5,835)	(839,514)	1,328,804
Ending Balance (in shares) at Jun. 30, 2021	58,554,559
Increase (Decrease) in Stockholders' Equity
Issuance of common stock under stock plan		11,038			11,038
Issuance of common stock under stock plan (in shares)	260,107
Stock-based compensation expense		24,324			24,324
Other comprehensive income (loss)			162		162
Net loss				(117,241)	(117,241)
Ending Balance at Sep. 30, 2021	$ 59	2,209,456	(5,673)	(956,755)	1,247,087
Ending Balance (in shares) at Sep. 30, 2021	58,814,666
Beginning Balance at Dec. 31, 2021	$ 59	2,250,250	(4,133)	(1,275,441)	$ 970,735
Beginning Balance (in shares) at Dec. 31, 2021	59,141,086				59,141,086
Increase (Decrease) in Stockholders' Equity
Issuance of common stock under stock plan	$ 1	1,297			$ 1,298
Issuance of common stock under stock plan (in shares)	414,888
Stock-based compensation expense		23,609			23,609
Other comprehensive income (loss)			(7,977)		(7,977)
Net loss				(105,999)	(105,999)
Ending Balance at Mar. 31, 2022	$ 60	2,275,156	(12,110)	(1,381,440)	881,666
Ending Balance (in shares) at Mar. 31, 2022	59,555,974
Beginning Balance at Dec. 31, 2021	$ 59	2,250,250	(4,133)	(1,275,441)	$ 970,735
Beginning Balance (in shares) at Dec. 31, 2021	59,141,086				59,141,086
Increase (Decrease) in Stockholders' Equity
Net loss					$ (398,871)
Ending Balance at Sep. 30, 2022	$ 60	2,329,385	(14,826)	(1,674,312)	$ 640,307
Ending Balance (in shares) at Sep. 30, 2022	59,808,492				59,808,492
Beginning Balance at Mar. 31, 2022	$ 60	2,275,156	(12,110)	(1,381,440)	$ 881,666
Beginning Balance (in shares) at Mar. 31, 2022	59,555,974
Increase (Decrease) in Stockholders' Equity
Issuance of common stock under stock plan		535			535
Issuance of common stock under stock plan (in shares)	92,274
Purchase of common stock under ESPP		1,872			1,872
Purchase of common stock under ESPP (in shares)	40,047
Stock-based compensation expense		25,524			25,524
Other comprehensive income (loss)			(2,138)		(2,138)
Net loss				(159,709)	(159,709)
Ending Balance at Jun. 30, 2022	$ 60	2,303,087	(14,248)	(1,541,149)	747,750
Ending Balance (in shares) at Jun. 30, 2022	59,688,295
Increase (Decrease) in Stockholders' Equity
Issuance of common stock under stock plan		2,030			2,030
Issuance of common stock under stock plan (in shares)	120,197
Stock-based compensation expense		24,268			24,268
Other comprehensive income (loss)			(578)		(578)
Net loss				(133,163)	(133,163)
Ending Balance at Sep. 30, 2022	$ 60	$ 2,329,385	$ (14,826)	$ (1,674,312)	$ 640,307
Ending Balance (in shares) at Sep. 30, 2022	59,808,492				59,808,492