Condensed Consolidated Statements of Operations and Comprehensive Loss - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021	Sep. 30, 2022	Sep. 30, 2021
Revenues:
Revenue	$ 65,977	$ 24,188	$ 165,255	$ 73,059
Cost and operating expenses:
Cost of sales	3,000	3,790	12,965	10,385
Research and development	127,981	84,419	359,579	244,157
Selling, general and administrative	57,608	49,806	173,354	141,093
Collaboration loss sharing	1,665	3,269	7,076	3,269
Total cost and operating expenses	190,254	141,284	552,974	398,904
Other income (expense):
Interest income (expense), net	(8,396)	552	(7,527)	1,923
Other income (expense), net	396	(522)	575	(1,109)
Total other income (expense), net	(8,000)	30	(6,952)	814
Loss before income taxes	(132,277)	(117,066)	(394,671)	(325,031)
Income tax expense	(886)	(175)	(4,200)	(368)
Net loss	(133,163)	(117,241)	(398,871)	(325,399)
Other comprehensive loss:
Unrealized losses on available-for-sale investments	(843)	(12)	(11,171)	(1,035)
Currency translation adjustments	265	174	478	577
Comprehensive loss	$ (133,741)	$ (117,079)	$ (409,564)	$ (325,857)
Net income (loss) per share - basic (in dollars per share)	$ (2.23)	$ (2.00)	$ (6.70)	$ (5.58)
Net income (loss) per share - diluted (in dollars per share)	$ (2.23)	$ (2.00)	$ (6.70)	$ (5.58)
Weighted-average number of common shares used in net loss per share - basic (in shares)	59,758	58,647	59,564	58,361
Weighted-average number of common shares used in net loss per share - diluted (in shares)	59,758	58,647	59,564	58,361
Product revenue, net
Revenues:
Revenue	$ 28,634	$ 17,270	$ 80,929	$ 37,658
Collaboration and license revenue
Revenues:
Revenue	9,843	$ 6,918	56,826	$ 35,401
License revenue - related party
Revenues:
Revenue	$ 27,500		$ 27,500