Stock-based Compensation - Stock-based Compensation Expense - By Classification (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Total stock based compensation expense
Stock-based compensation expense	$ 25,347	$ 24,307	$ 48,746	$ 44,991
Research and Development
Total stock based compensation expense
Stock-based compensation expense	10,497	10,485	20,538	19,432
General and Administrative Expense
Total stock based compensation expense
Stock-based compensation expense	$ 14,850	$ 13,822	$ 28,208	$ 25,559