Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021
Cash flows from operating activities
Net loss	$ (265,709)	$ (208,159)
Adjustments to reconcile net income (loss) to net cash provided by (used in) operating activities:
Depreciation and amortization	3,098	3,200
Noncash lease expense	4,107	3,073
Stock-based compensation	48,746	44,991
Other	550	1,352
Changes in assets and liabilities:
Accounts receivable	(2,128)	(18,407)
Unbilled accounts receivable	9,591	4,446
Inventory	(14,694)	(4,542)
Prepaid expenses and other current assets	(16,314)	(755)
Other assets	(13,188)	(3,829)
Accounts payable	6,589	(2,544)
Accrued expenses	441	(1,044)
Other long-term liabilities	6,157
Deferred revenue	(14,438)	(2,880)
Operating lease liabilities	(3,790)	(3,845)
Net cash used in operating activities	(250,982)	(188,943)
Cash flows from investing activities
Purchases of property and equipment	(3,709)	(835)
Purchases of investments	(39,937)	(382,644)
Maturities of investments	79,623	400,500
Net cash provided by investing activities	35,977	17,021
Cash flows from financing activities
Gross proceeds from the sale of future royalties	175,000
Net proceeds from stock option exercises and employee stock purchase plan	3,762	21,865
Net cash provided by financing activities	178,762	21,865
Net decrease in cash, cash equivalents, and restricted cash	(36,243)	(150,057)
Cash, cash equivalents and restricted cash at beginning of period	215,119	689,804
Effect of exchange rate changes on cash, cash equivalents and restricted cash	(306)	(259)
Cash, cash equivalents and restricted cash at end of period	178,570	539,488
Supplemental cash flow information
Debt issuance costs incurred but unpaid at period end	5,022
Property and equipment purchases unpaid at period end	1,829	230
Cash paid for taxes, net	$ 771	$ 598