Condensed Consolidated Statements of Operations and Comprehensive Loss - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Revenues:
Revenue	$ 36,547	$ 27,295	$ 99,278	$ 48,871
Cost and operating expenses:
Cost of sales	4,886	6,493	9,964	6,595
Research and development	128,466	80,027	231,599	159,738
Selling, general and administrative	58,688	49,286	115,747	91,288
Collaboration loss sharing	2,145		5,410
Total cost and operating expenses	194,185	135,806	362,720	257,621
Other income (expense):
Interest income, net	427	633	869	1,371
Other income (expense), net	632	(373)	177	(587)
Total other income	1,059	260	1,046	784
Loss before income taxes	(156,579)	(108,251)	(262,396)	(207,966)
Income tax expense	(3,130)	(193)	(3,313)	(193)
Net loss	(159,709)	(108,444)	(265,709)	(208,159)
Other comprehensive loss:
Unrealized losses on available-for-sale investments	(2,308)	(624)	(10,328)	(1,024)
Currency translation adjustments	170	(114)	213	404
Comprehensive loss	$ (161,847)	$ (109,182)	$ (275,824)	$ (208,779)
Net income (loss) per share - basic (in dollars per share)	$ (2.68)	$ (1.86)	$ (4.47)	$ (3.58)
Net income (loss) per share - diluted (in dollars per share)	$ (2.68)	$ (1.86)	$ (4.47)	$ (3.58)
Weighted-average number of common shares used in net loss per share - basic (in shares)	59,617	58,406	59,465	58,216
Weighted-average number of common shares used in net loss per share - diluted (in shares)	59,617	58,406	59,465	58,216
Product revenue, net
Revenues:
Revenue	$ 28,454	$ 11,433	$ 52,295	$ 20,388
Collaboration revenue
Revenues:
Revenue	$ 8,093	$ 15,862	$ 46,983	$ 28,483