Stock-based Compensation (Tables)

6 Months Ended

Jun. 30, 2022

Table Text Blocks

Summary of stock option activity

		Weighted-Average
	Shares		Exercise Price
Outstanding at December 31, 2021	5,682,022	$	69.37
Granted	1,013,605		61.67
Exercised	(119,121)		15.39
Canceled	(189,289)		79.11
Outstanding at June 30, 2022	6,387,217	$	68.86
Exercisable at June 30, 2022	3,881,205	$	64.81

Summary of restricted stock units activity

		Weighted-Average
	Shares	Grant Date Fair Value
Unvested shares at December 31, 2021	1,590,160	$	83.85
Granted	743,828		61.43
Vested	(388,087)		79.36
Forfeited	(88,534)		78.98
Unvested shares at June 30, 2022	1,857,367	$	76.02

Summary of stock-based compensation expense, allocation by type of awards and recognition in statements of operations

	Three Months Ended				Six Months Ended
		June 30,				June 30,
		2022		2021		2022		2021
Stock options	$	12,811	$	14,965	$	25,755	$	29,107
Restricted stock units		12,396		9,270		22,782		16,064
Employee stock purchase plan		317		287		596		563
Subtotal		25,524		24,522		49,133		45,734
Capitalized stock-based compensation costs		(177)		(215)		(387)		(743)
Stock-based compensation expense included in total cost and operating expenses	$	25,347	$	24,307	$	48,746	$	44,991

Stock-based compensation expense, that is included in operating expenses, by classification within the unaudited condensed consolidated statements of operations and comprehensive loss is as follows (in thousands):

	Three Months Ended				Six Months Ended
	June 30,				June 30,
	2022		2021		2022		2021
Research and development	$	10,497	$	10,485	$	20,538	$	19,432
Selling, general and administrative		14,850		13,822		28,208		25,559
Total	$	25,347	$	24,307	$	48,746	$	44,991