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Collaboration and License Agreements - General Information (Details)
$ in Thousands
1 Months Ended 3 Months Ended 6 Months Ended 12 Months Ended
Jul. 13, 2020
USD ($)
Oct. 15, 2019
USD ($)
item
Jun. 01, 2018
USD ($)
item
Jul. 31, 2020
USD ($)
Oct. 31, 2019
USD ($)
Jun. 30, 2018
USD ($)
Mar. 31, 2018
USD ($)
Mar. 31, 2016
USD ($)
item
Jun. 30, 2020
USD ($)
Dec. 31, 2019
USD ($)
item
Jun. 30, 2019
USD ($)
Jun. 30, 2018
USD ($)
Jun. 30, 2020
USD ($)
Milestone
Jun. 30, 2019
USD ($)
Dec. 31, 2019
USD ($)
Collaboration Agreements                              
Collaboration revenue                 $ 8,343   $ 5,110   $ 14,510 $ 5,840  
Current portion of deferred revenue                 $ 8,017 $ 6,160     $ 8,017   $ 6,160
Roche | Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date [Axis]: 2020-07-01                              
Collaboration Agreements                              
Research and development services, performance period                 4 years 9 months 18 days       4 years 9 months 18 days    
Collaboration | Clementia                              
Collaboration Agreements                              
Non-refundable upfront payment received   $ 25,000                          
Milestone payment received         $ 20,000                    
Cash milestone payment   20,000             $ 20,000 20,000     $ 20,000   20,000
Milestone other payment   490,000                          
Purchase specified manufacturing inventory   $ 1,500                          
Number of performance obligations | item   3                          
Purchase of existing manufacturing inventory   $ 1,200                          
Purchase of in-process manufacturing inventory   $ 300                          
Number of material promises | item   4                          
Initial cash payment   $ 46,500                          
Collaboration revenue                 300   0   300 0 46,200
Deferred revenue                 0 0     0   0
Collaboration | Clementia | Subsequent Event                              
Collaboration Agreements                              
Milestone payment received       $ 20,000                      
Collaboration | C Stone                              
Collaboration Agreements                              
Non-refundable upfront payment received     $ 40,000                 $ 40,000      
Eligible milestone payments     $ 346,000                        
Number of performance obligations | item     3                        
Licensed product term from first commercial sale     12 years                        
Number of materials components | item     2                        
Number of option rights to obtain exclusive license | item     3                        
Number of potential collaboration programs | item     3                        
Number of material promises | item     6                        
Number of collaboration programs with exclusive commercialization rights for licensed products | item     3                        
Initial cash payment     $ 40,000                        
Collaboration revenue                 1,263   4,144   3,397 4,144  
Deferred revenue                 0 $ 0     $ 0   $ 0
Collaboration | C Stone | Development and regulatory milestones                              
Collaboration Agreements                              
Eligible milestone payments     118,500                        
Number of milestones acheived | Milestone                         1    
Collaboration revenue                         $ 2,000    
Collaboration | C Stone | Sales-based milestones                              
Collaboration Agreements                              
Eligible milestone payments     $ 227,500                        
Collaboration | Roche                              
Collaboration Agreements                              
Non-refundable upfront payment received               $ 45,000              
Number of small molecule therapeutics targeting kinases | item               5              
Number of option rights to obtain exclusive license | item               5              
Number of potential collaboration programs | item               4   4          
Initial cash payment             $ 45,000 $ 45,000              
Collaboration revenue                 1,109   966   1,684 1,697  
Deferred revenue                 44,700       44,700    
Total eligible contingent option fees and milestone payments               940,000              
Eligible option fees and milestones prior to licensing for all potential collaboration programs               $ 190,000              
Current portion of deferred revenue                 8,000       8,000    
Achieved research milestone payment received which will be recognized over period of performance         $ 8,000 $ 10,000                  
Revenue recognized, change in contract liability                 $ 1,061   $ 966   $ 2,050 $ 1,953  
Collaboration | Roche | Subsequent Event                              
Collaboration Agreements                              
Non-refundable upfront payment received $ 675,000                            
Total eligible contingent option fees and milestone payments $ 927,000                            
Collaboration | Roche | Prior To Exercise License Right Option                              
Collaboration Agreements                              
Written termination notice period               120 days              
Collaboration | Roche | Exercise Of License Right Option                              
Collaboration Agreements                              
Number of collaboration programs with exclusive commercialization rights for licensed products | item               2              
Number of collaboration programs with specified commercial rights for each party | item               2              
Collaboration | Roche | Exercise Of License Option Product Not Commercially Sold                              
Collaboration Agreements                              
Written termination notice period               120 days              
Collaboration | Roche | Exercise Of License Option Product Commercially Sold                              
Collaboration Agreements                              
Written termination notice period               180 days