Condensed Consolidated Statements of Operations and Comprehensive Loss - USD ($) shares in Thousands, $ in Thousands	3 Months Ended
	Mar. 31, 2020	Mar. 31, 2019
Revenues:
Total revenues	$ 6,167	$ 730
Cost and operating expenses
Cost of sales	24
Research and development	84,146	74,250
Selling, general and administrative	35,655	16,553
Total cost and operating expenses	119,825	90,803
Other income (expense):
Interest income (expense), net	2,904	2,710
Other income (expense), net	(201)	(44)
Total other income	2,703	2,666
Net loss	(110,955)	(87,407)
Other comprehensive loss:
Unrealized gain (losses) on available-for-sale investments	2,492	270
Currency translation adjustments	(27)	(15)
Comprehensive loss	$ (108,490)	$ (87,152)
Net loss per share - basic and diluted	$ (2.11)	$ (1.98)
Weighted-average number of common shares used in net loss per share - basic and diluted	52,655	44,097
Product revenue, net
Revenues:
Total revenues	$ 3,458
Collaboration revenue
Revenues:
Total revenues	$ 2,709	$ 730