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Collaborations (Details)
$ in Thousands
1 Months Ended 3 Months Ended 12 Months Ended
Mar. 31, 2016
USD ($)
item
Mar. 31, 2015
USD ($)
item
Mar. 31, 2017
USD ($)
Mar. 31, 2016
USD ($)
Jun. 30, 2015
USD ($)
Dec. 31, 2016
USD ($)
Collaborations            
Collaboration revenue     $ 5,840 $ 6,856    
Unbilled accounts receivable for reimbursable research and development costs     2,826     $ 3,577
Roche Agreement            
Collaborations            
Non-refundable upfront payment received $ 45,000          
Number of deliverables | item 5          
Collaboration revenue     1,400     $ 200
Number of collaboration programs with agreed upon targets | item 3          
Roche Agreement | Maximum            
Collaborations            
Number of potential collaboration programs | item 5          
Number of collaboration programs to select targets | item 2          
Total eligible contingent option fees and milestone payments $ 965,000     965,000    
Eligible option fees and milestones prior to licensing for all potential collaboration programs $ 215,000          
Roche Agreement | Exercise Of License Right Option | Maximum            
Collaborations            
Number of collaboration programs with specified commercial rights for each party | item 2          
Roche Agreement | Roche            
Collaborations            
Number of option rights to obtain exclusive license | item 5          
Roche Agreement | Roche | Prior To Exercise License Right Option            
Collaborations            
Written termination notice period 120 days          
Roche Agreement | Roche | Exercise Of License Right Option | Maximum            
Collaborations            
Number of collaboration programs with exclusive commercialization rights for licensed products | item 3          
Roche Agreement | Roche | Exercise Of License Option Product Not Commercially Sold            
Collaborations            
Written termination notice period 120 days          
Roche Agreement | Roche | Exercise Of License Option Product Commercially Sold            
Collaborations            
Written termination notice period 180 days          
Alexion            
Collaborations            
Collaborative partner's funding responsibility of research and development costs incurred under the research plan (as a percent)   100.00%        
Non-refundable upfront payment received   $ 15,000   15,000    
Payment receivable upon achievement of milestone   $ 250,000        
Royalty term from first commercial sale, option 1   10 years        
Royalty term from first commercial sale, option 2   15 years        
Written termination notice period   90 days        
Number of deliverables | item   3        
Refund provisions   $ 0        
Non-substantive milestone payment previously     1,750 1,750    
Collaboration revenue     4,400 6,600    
Reimbursable research and development costs recognized     2,800 4,200    
Reimbursable research and development costs received     3,600      
Unbilled accounts receivable for reimbursable research and development costs     2,800      
Alexion | Pre-clinical milestone for first licensed product            
Collaborations            
Achieved milestone payment received which will be recognized over period of performance         $ 1,800  
Achieved milestone payment received which will be recognized upon acheivment       $ 750    
Revenue recognized from milestone     $ 2,000      
Alexion | Pre-clinical milestone for first licensed product | Maximum            
Collaborations            
Payment receivable upon achievement of milestone   6,000        
Alexion | Development milestone for first licensed product | Maximum            
Collaborations            
Payment receivable upon achievement of milestone   83,000        
Alexion | Development milestone for second licensed product | Maximum            
Collaborations            
Payment receivable upon achievement of milestone   61,500        
Alexion | Commercial milestone            
Collaborations            
Payment receivable upon achievement of milestone   $ 51,000