Exhibit 107

Calculation of Filing Fee Tables

Form S-3

(Form Type)

Blueprint Medicines Corporation

(Exact Name of Registrant as Specified in its Charter)

Table 1: Newly Registered and Carry Forward Securities

		Security Type	Security Class Title	Fee Calculation or Carry Forward Rule	Amount Registered		Proposed Maximum Offering Price Per Unit		Maximum Aggregate Offering Price		Fee Rate		Amount of Registration Fee		Carry Forward Form Type		Carry Forward File Number		Carry Forward Initial effective date		Filing Fee Previously Paid In Connection with Unsold Securities to be Carried Forward
Newly Registered Securities
Fees to Be Paid		Equity	Common Stock, par value $0.001 per share	Rule 456(b) and Rule 457(r)		(1)		(1)		(1)		(2)		(2)		—		—		—		—
		Equity	Preferred Stock, par value $0.001 per share	Rule 456(b) and Rule 457(r)		(1)		(1)		(1)		(2)		(2)		—		—		—		—
		Debt	Debt Securities	Rule 456(b) and Rule 457(r)		(1)		(1)		(1)		(2)		(2)		—		—		—		—
		Other	Purchase Contracts	Rule 456(b) and Rule 457(r)		(1)		(1)		(1)		(2)		(2)		—		—		—		—
		Other	Purchase Units	Rule 456(b) and Rule 457(r)		(1)		(1)		(1)		(2)		(2)		—		—		—		—
		Other	Warrants	Rule 456(b) and Rule 457(r)		(1)		(1)		(1)		(2)		(2)		—		—		—		—
Fees Previously Paid		—	—	—		—		—		—		—		—		—		—		—		—
Carry Forward Securities
Carry Forward Securities		—	—	—		—		—		—		—		—		—		—		—		—
		Total Offering Amount(3)								—				(2)
		Total Fees Previously Paid												—
	Total Fee Offsets													—
		Net Fee Due												(2)

(1)	An indeterminate amount of the securities of each identified class is being registered as may from time to time be offered hereunder at indeterminate prices, along with an indeterminate number of securities that may be issued upon exercise, settlement, exchange or conversion of securities offered or sold hereunder. Pursuant to Rule 416 under the Securities Act of 1933, as amended (the “Securities Act”), this registration statement also covers any additional securities that may be offered or issued in connection with any stock split, stock dividend or pursuant to anti-dilution provisions of any of the securities. Separate consideration may or may not be received for securities that are issuable upon conversion, exercise or exchange of other securities.
(2)	In accordance with Rules 456(b) and 457(r) under the Securities Act, the registrant is deferring payment of all registration fees and will pay the registration fees subsequently in advance or on a “pay-as-you-go” basis.
(3)	The securities registered hereunder may be sold separately or in a combination with other securities registered hereby.