SCHEDULE 13G 0001595082 XXXXXXXX LIVE Common Stock, par value $0.001 per share 07/14/2025 0001597264 Blueprint Medicines Corp 09627Y109 45 SIDNEY STREET CAMBRIDGE MA 02139 Rule 13d-1(c) M.H. Davidson & Co. b NY 0.00 0.00 0.00 0.00 0.00 N 0 PN Davidson Kempner Arbitrage, Equities and Relative Value LP b E9 0.00 0.00 0.00 0.00 0.00 N 0 PN Davidson Kempner Capital Management LP b DE 0.00 0.00 0.00 0.00 0.00 N 0 PN Anthony A. Yoseloff b X1 0.00 0.00 0.00 0.00 0.00 N 0 IN Blueprint Medicines Corp 45 Sidney Street, Cambridge, Massachusetts 02139 This Statement is filed by each of the entities and persons listed below, all of whom together are referred to herein as the "Reporting Persons": (i) M.H. Davidson & Co., a New York limited partnership ("CO"). M.H. Davidson & Co. GP, L.L.C., a Delaware limited liability company ("CO GP"), is the general partner of CO and Davidson Kempner Liquid GP Topco LLC, a Delaware limited liability company, is the managing member of CO GP. DKCM (as defined below) is responsible for the voting and investment decisions of CO; (ii) Davidson Kempner Arbitrage, Equities and Relative Value LP, a Cayman Islands exempted limited partnership ("DKAERV"). Davidson Kempner Multi-Strategy GP II LLC, a Delaware limited liability company ("DKAERV GP"), is the general partner of DKAERV and Davidson Kempner Liquid GP Topco LLC, a Delaware limited liability company, is the managing member of DKAERV GP. DKCM is responsible for the voting and investment decisions of DKAERV; (iii) Davidson Kempner Capital Management LP, a Delaware limited partnership and a registered investment adviser with the U.S. Securities and Exchange Commission, acts as investment manager to a certain managed account (the "Managed Account") and each of CO and DKAERV ("DKCM"). DKCM GP LLC, a Delaware limited liability company, is the general partner of DKCM. The managing members of DKCM are Anthony A. Yoseloff, Conor Bastable, Shulamit Leviant, Morgan P. Blackwell, Patrick W. Dennis, Gabriel T. Schwartz, Zachary Z. Altschuler, Joshua D. Morris, Suzanne K. Gibbons, Gregory S. Feldman, Melanie Levine and James Li; and Anthony A. Yoseloff, through DKCM, is responsible for the voting and investment decisions relating to the common stock, par value $0.001 per share ("Common Stock") of Blueprint Medicines Corporation (the "Company") that were held by the Managed Account, CO and DKAERV. The address of the principal business office of each of the Reporting Persons is c/o Davidson Kempner Capital Management LP, 9 West 57th Street, 29th Floor, New York, NY 10019. (i) CO - a New York limited partnership (ii) DKAERV - a Cayman Islands exempted limited partnership (iii) DKCM - a Delaware limited partnership (iv) Anthony A. Yoseloff - United States Y The information required by Item 4(a) is set forth in Row 9 of the cover page for each of the Reporting Persons and is incorporated herein by reference. As of the date of the event which requires the filing of this Schedule 13G, the Reporting Persons may have been deemed to beneficially own more than 5% of the shares of Common Stock outstanding. 0% The information required by Item 4(c)(i) is set forth in Row 5 of the cover page for each of the Reporting Persons and is incorporated herein by reference. The information required by Item 4(c)(ii) is set forth in Row 6 of the cover page for each of the Reporting Persons and is incorporated herein by reference. The information required by Item 4(c)(iii) is set forth in Row 7 of the cover page for each of the Reporting Persons and is incorporated herein by reference. The information required by Item 4(c)(iv) is set forth in Row 8 of the cover page for each of the Reporting Persons and is incorporated herein by reference. N Y Y Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. M.H. Davidson & Co. /s/ Anthony A. Yoseloff 07/21/2025 Davidson Kempner Arbitrage, Equities and Relative Value LP /s/ Anthony A. Yoseloff 07/21/2025 Davidson Kempner Capital Management LP /s/ Anthony A. Yoseloff 07/21/2025 Anthony A. Yoseloff /s/ Anthony A. Yoseloff 07/21/2025