Fair Value Measurements - Schedule of Fair Value of Financial Assets (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021	Sep. 30, 2022	Sep. 30, 2021	Dec. 31, 2021
Assets, Fair Value Disclosure [Abstract]
Cash Equivalents, Fair Value	$ 437,911		$ 437,911		$ 221,382
Marketable Securities, Fair Value	2,236,643		2,236,643		2,742,571
Total Financial Assets, Fair Value	2,705,989		2,705,989		3,013,121
Unrealized gain on equity investments	708	$ 0	24,121	$ 0
Fair Value to Amortized Cost
Amortized Cost	2,276,292		2,276,292		2,748,697
Unrealized Gains	0		0		144
Unrealized Losses	(39,649)		(39,649)		(6,270)
Fair Value	2,236,643		2,236,643		2,742,571
Level I
Assets, Fair Value Disclosure [Abstract]
Cash Equivalents, Fair Value	377,355		377,355		221,382
Total Financial Assets, Fair Value	1,567,267		1,567,267		1,283,429
Level II
Assets, Fair Value Disclosure [Abstract]
Cash Equivalents, Fair Value	60,556		60,556		0
Total Financial Assets, Fair Value	1,138,722		1,138,722		1,729,692
Level III
Assets, Fair Value Disclosure [Abstract]
Cash Equivalents, Fair Value	0		0		0
Total Financial Assets, Fair Value	0		0		0
Commercial paper
Assets, Fair Value Disclosure [Abstract]
Marketable Securities, Fair Value	3,487		3,487		141,274
Fair Value to Amortized Cost
Amortized Cost	3,487		3,487		141,274
Unrealized Gains	0		0		0
Unrealized Losses	0		0		0
Fair Value	3,487		3,487		141,274
Commercial paper | Level I
Assets, Fair Value Disclosure [Abstract]
Marketable Securities, Fair Value	0		0		0
Fair Value to Amortized Cost
Fair Value	0		0		0
Commercial paper | Level II
Assets, Fair Value Disclosure [Abstract]
Marketable Securities, Fair Value	3,487		3,487		141,274
Fair Value to Amortized Cost
Fair Value	3,487		3,487		141,274
Commercial paper | Level III
Assets, Fair Value Disclosure [Abstract]
Marketable Securities, Fair Value	0		0		0
Fair Value to Amortized Cost
Fair Value	0		0		0
Certificate of deposits
Assets, Fair Value Disclosure [Abstract]
Marketable Securities, Fair Value	11,422		11,422		44,931
Fair Value to Amortized Cost
Fair Value	11,422		11,422		44,931
Certificate of deposits | Level I
Assets, Fair Value Disclosure [Abstract]
Marketable Securities, Fair Value	0		0		0
Fair Value to Amortized Cost
Fair Value	0		0		0
Certificate of deposits | Level II
Assets, Fair Value Disclosure [Abstract]
Marketable Securities, Fair Value	11,422		11,422		44,931
Fair Value to Amortized Cost
Fair Value	11,422		11,422		44,931
Certificate of deposits | Level III
Assets, Fair Value Disclosure [Abstract]
Marketable Securities, Fair Value	0		0		0
Fair Value to Amortized Cost
Fair Value	0		0		0
U.S. government notes
Assets, Fair Value Disclosure [Abstract]
Marketable Securities, Fair Value	1,169,899		1,169,899		1,057,810
Fair Value to Amortized Cost
Amortized Cost	1,187,901		1,187,901		1,060,716
Unrealized Gains	0		0		3
Unrealized Losses	(18,002)		(18,002)		(2,909)
Fair Value	1,169,899		1,169,899		1,057,810
U.S. government notes | Level I
Assets, Fair Value Disclosure [Abstract]
Marketable Securities, Fair Value	1,169,899		1,169,899		1,057,810
Fair Value to Amortized Cost
Fair Value	1,169,899		1,169,899		1,057,810
U.S. government notes | Level II
Assets, Fair Value Disclosure [Abstract]
Marketable Securities, Fair Value	0		0		0
Fair Value to Amortized Cost
Fair Value	0		0		0
U.S. government notes | Level III
Assets, Fair Value Disclosure [Abstract]
Marketable Securities, Fair Value	0		0		0
Fair Value to Amortized Cost
Fair Value	0		0		0
Corporate bonds
Assets, Fair Value Disclosure [Abstract]
Marketable Securities, Fair Value	883,784		883,784		1,252,226
Fair Value to Amortized Cost
Amortized Cost	902,133		902,133		1,255,149
Unrealized Gains	0		0		105
Unrealized Losses	(18,349)		(18,349)		(3,028)
Fair Value	883,784		883,784		1,252,226
Corporate bonds | Level I
Assets, Fair Value Disclosure [Abstract]
Marketable Securities, Fair Value	0		0		0
Fair Value to Amortized Cost
Fair Value	0		0		0
Corporate bonds | Level II
Assets, Fair Value Disclosure [Abstract]
Marketable Securities, Fair Value	883,784		883,784		1,252,226
Fair Value to Amortized Cost
Fair Value	883,784		883,784		1,252,226
Corporate bonds | Level III
Assets, Fair Value Disclosure [Abstract]
Marketable Securities, Fair Value	0		0		0
Fair Value to Amortized Cost
Fair Value	0		0		0
Agency securities
Assets, Fair Value Disclosure [Abstract]
Marketable Securities, Fair Value	179,473		179,473		291,261
Fair Value to Amortized Cost
Amortized Cost	182,771		182,771		291,558
Unrealized Gains	0		0		36
Unrealized Losses	(3,298)		(3,298)		(333)
Fair Value	179,473		179,473		291,261
Agency securities | Level I
Assets, Fair Value Disclosure [Abstract]
Marketable Securities, Fair Value	0		0		0
Fair Value to Amortized Cost
Fair Value	0		0		0
Agency securities | Level II
Assets, Fair Value Disclosure [Abstract]
Marketable Securities, Fair Value	179,473		179,473		291,261
Fair Value to Amortized Cost
Fair Value	179,473		179,473		291,261
Agency securities | Level III
Assets, Fair Value Disclosure [Abstract]
Marketable Securities, Fair Value	0		0		0
Fair Value to Amortized Cost
Fair Value	0		0		0
Marketable equity securities
Assets, Fair Value Disclosure [Abstract]
Marketable Securities, Fair Value	15,753		15,753		0
Fair value of securities reclassified			8,300
Unrealized gain on equity investments	(900)		7,500
Fair Value to Amortized Cost
Fair Value	15,753		15,753		0
Marketable equity securities | Level I
Assets, Fair Value Disclosure [Abstract]
Marketable Securities, Fair Value	15,753		15,753		0
Fair Value to Amortized Cost
Fair Value	15,753		15,753		0
Marketable equity securities | Level II
Assets, Fair Value Disclosure [Abstract]
Marketable Securities, Fair Value	0		0		0
Fair Value to Amortized Cost
Fair Value	0		0		0
Marketable equity securities | Level III
Assets, Fair Value Disclosure [Abstract]
Marketable Securities, Fair Value	0		0		0
Fair Value to Amortized Cost
Fair Value	0		0		0
Marketable Securities
Assets, Fair Value Disclosure [Abstract]
Marketable Securities, Fair Value	2,263,818		2,263,818		2,787,502
Fair Value to Amortized Cost
Fair Value	2,263,818		2,263,818		2,787,502
Marketable Securities | Level I
Assets, Fair Value Disclosure [Abstract]
Marketable Securities, Fair Value	1,185,652		1,185,652		1,057,810
Fair Value to Amortized Cost
Fair Value	1,185,652		1,185,652		1,057,810
Marketable Securities | Level II
Assets, Fair Value Disclosure [Abstract]
Marketable Securities, Fair Value	1,078,166		1,078,166		1,729,692
Fair Value to Amortized Cost
Fair Value	1,078,166		1,078,166		1,729,692
Marketable Securities | Level III
Assets, Fair Value Disclosure [Abstract]
Marketable Securities, Fair Value	0		0		0
Fair Value to Amortized Cost
Fair Value	0		0		0
Money market funds - restricted
Assets, Fair Value Disclosure [Abstract]
Other Assets, Fair Value	4,260		4,260		4,237
Money market funds - restricted | Level I
Assets, Fair Value Disclosure [Abstract]
Other Assets, Fair Value	4,260		4,260		4,237
Money market funds - restricted | Level II
Assets, Fair Value Disclosure [Abstract]
Other Assets, Fair Value	0		0		0
Money market funds - restricted | Level III
Assets, Fair Value Disclosure [Abstract]
Other Assets, Fair Value	0		0		0
Money market funds
Assets, Fair Value Disclosure [Abstract]
Cash Equivalents, Fair Value	353,987		353,987		221,382
Money market funds | Level I
Assets, Fair Value Disclosure [Abstract]
Cash Equivalents, Fair Value	353,987		353,987		221,382
Money market funds | Level II
Assets, Fair Value Disclosure [Abstract]
Cash Equivalents, Fair Value	0		0		0
Money market funds | Level III
Assets, Fair Value Disclosure [Abstract]
Cash Equivalents, Fair Value	0		0		0
Certificate of deposits
Assets, Fair Value Disclosure [Abstract]
Cash Equivalents, Fair Value	14,556		14,556		0
Certificate of deposits | Level I
Assets, Fair Value Disclosure [Abstract]
Cash Equivalents, Fair Value	0		0		0
Certificate of deposits | Level II
Assets, Fair Value Disclosure [Abstract]
Cash Equivalents, Fair Value	14,556		14,556		0
Certificate of deposits | Level III
Assets, Fair Value Disclosure [Abstract]
Cash Equivalents, Fair Value	0		0		0
U.S. government notes
Assets, Fair Value Disclosure [Abstract]
Cash Equivalents, Fair Value	23,368		23,368		0
U.S. government notes | Level I
Assets, Fair Value Disclosure [Abstract]
Cash Equivalents, Fair Value	23,368		23,368		0
U.S. government notes | Level II
Assets, Fair Value Disclosure [Abstract]
Cash Equivalents, Fair Value	0		0		0
U.S. government notes | Level III
Assets, Fair Value Disclosure [Abstract]
Cash Equivalents, Fair Value	0		0		0
Agency securities
Assets, Fair Value Disclosure [Abstract]
Cash Equivalents, Fair Value	46,000		46,000		0
Agency securities | Level I
Assets, Fair Value Disclosure [Abstract]
Cash Equivalents, Fair Value	0		0		0
Agency securities | Level II
Assets, Fair Value Disclosure [Abstract]
Cash Equivalents, Fair Value	46,000		46,000		0
Agency securities | Level III
Assets, Fair Value Disclosure [Abstract]
Cash Equivalents, Fair Value	$ 0		$ 0		$ 0