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Income Taxes - Effective Income Tax Reconciliation (Details)
12 Months Ended
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Income Tax Disclosure [Abstract]      
U.S. federal statutory income tax 35.00% 35.00% 35.00%
State tax, net of federal benefit (1.70%) (0.03%) (1.35%)
Foreign tax differential (7.62%) (3.24%) (2.16%)
Tax credits (3.84%) (4.24%) (6.72%)
Change in valuation allowance 1.95% 1.71% 2.84%
Permanent items (1.10%) (1.02%) (1.32%)
Uncertain tax positions and associated interest 0.77% (1.46%) (3.95%)
Stock-based compensation (23.74%) (2.81%) (5.29%)
Tax Cuts and Jobs Act 11.14% 0.00% 0.00%
Other, net 0.00% 0.05% 0.01%
Total provision for income taxes 10.86% 23.96% 17.06%