Condensed Statements of Stockholders' Equity (Unaudited) - USD ($) $ in Thousands	Total	Common Stock	Additional Paid-In Capital	Accumulated Other Comprehensive Income (Loss)	Accumulated Deficit
Balance at Dec. 31, 2020	$ 1,109,898	$ 5	$ 1,389,860	$ 209	$ (280,176)
Balance, Shares at Dec. 31, 2020		48,678,540
Issuance of common stock under equity incentive plans	9,679		9,679
Issuance of common stock under equity incentive plans, Shares		438,500
Stock-based compensation expense	17,278		17,278
Net loss	(35,504)				(35,504)
Other comprehensive loss	(186)			(186)
Balance at Mar. 31, 2021	1,101,165	$ 5	1,416,817	23	(315,680)
Balance, Shares at Mar. 31, 2021		49,117,040
Balance at Dec. 31, 2020	1,109,898	$ 5	1,389,860	209	(280,176)
Balance, Shares at Dec. 31, 2020		48,678,540
Net loss	(91,777)
Balance at Jun. 30, 2021	1,067,507	$ 5	1,439,453	2	(371,953)
Balance, Shares at Jun. 30, 2021		49,391,738
Balance at Mar. 31, 2021	1,101,165	$ 5	1,416,817	23	(315,680)
Balance, Shares at Mar. 31, 2021		49,117,040
Issuance of common stock under equity incentive plans	8,398		8,398
Issuance of common stock under equity incentive plans, Shares		253,037
Shares issued under employee stock purchase plan, Shares		21,661
Shares issued under employee stock purchase plan	943		943
Stock-based compensation expense	13,295		13,295
Net loss	(56,273)				(56,273)
Other comprehensive loss	(21)			(21)
Balance at Jun. 30, 2021	1,067,507	$ 5	1,439,453	2	(371,953)
Balance, Shares at Jun. 30, 2021		49,391,738
Balance at Dec. 31, 2021	$ 954,425	$ 5	1,472,421	(1,274)	(516,727)
Balance, Shares at Dec. 31, 2021	49,582,638	49,582,638
Issuance of common stock under equity incentive plans	$ 396		396
Issuance of common stock under equity incentive plans, Shares		81,835
Stock-based compensation expense	15,089		15,089
Net loss	(74,445)				(74,445)
Other comprehensive loss	(4,118)			(4,118)
Balance at Mar. 31, 2022	891,347	$ 5	1,487,906	(5,392)	(591,172)
Balance, Shares at Mar. 31, 2022		49,664,473
Balance at Dec. 31, 2021	$ 954,425	$ 5	1,472,421	(1,274)	(516,727)
Balance, Shares at Dec. 31, 2021	49,582,638	49,582,638
Net loss	$ (197,533)
Balance at Jun. 30, 2022	$ 793,022	$ 5	1,514,191	(6,914)	(714,260)
Balance, Shares at Jun. 30, 2022	49,885,036	49,885,036
Balance at Mar. 31, 2022	$ 891,347	$ 5	1,487,906	(5,392)	(591,172)
Balance, Shares at Mar. 31, 2022		49,664,473
Issuance of common stock under equity incentive plans	7,863		7,863
Issuance of common stock under equity incentive plans, Shares		187,644
Shares issued under employee stock purchase plan, Shares		32,919
Shares issued under employee stock purchase plan	1,111		1,111
Stock-based compensation expense	17,311		17,311
Net loss	(123,088)				(123,088)
Other comprehensive loss	(1,522)			(1,522)
Balance at Jun. 30, 2022	$ 793,022	$ 5	$ 1,514,191	$ (6,914)	$ (714,260)
Balance, Shares at Jun. 30, 2022	49,885,036	49,885,036