X0202 SCHEDULE 13G/A 0001493152-26-022232 0001595855 XXXXXXXX LIVE 5 Common Stock, no par value 05/21/2026 0001655923 Alpha Cognition Inc. 02074J501 1452 Hughes Rd. Ste. 200 Grapevine TX 76051 Rule 13d-1(c) Opaleye Management Inc. MA 0.00 2620369.00 0.00 2620369.00 2620369.00 N 12.03 IA CO Includes shares held in a managed account over which the Adviser has shared voting and dispositive power. Opaleye, L.P. DE 0.00 2530369.00 0.00 2530369.00 2530369.00 N 11.62 PN Based on 21,774,104 shares of common stock outstanding as reported by Alpha Cognition Inc. in its Form 10-Q filed with the SEC on 05/14/2026. James Silverman X1 0.00 2620369.00 0.00 2620369.00 2620369.00 N 12.03 IN Includes shares held in a managed account over which the Adviser has shared voting and dispositive power. Alpha Cognition Inc. 1452 Hughes Rd. Ste. 200, Grapevine, TX 76051 This statement is filed jointly by (i) Opaleye Management Inc. (the "Adviser"), (ii) Opaleye, L.P. (the "Fund"), and (iii) James Silverman (collectively, the "Reporting Persons") with respect to shares of common stock held directly by the Fund and in a managed account advised by the Adviser. The Adviser serves as investment adviser to the Fund. Mr. Silverman is the controlling person of the Adviser. The filing of this statement should not be construed as an admission that any of the Reporting Persons is, for purposes of Section 13 of the Securities Exchange Act of 1934, as amended, the beneficial owner of any of the shares reported herein. One Boston Place, 26th Floor, Boston, MA 02108 Opaleye Management Inc., Massachusetts, Opaleye, L.P., Delaware, James Silverman, USA Y 2,620,369.00 12.03 % 0 2,620,369.00 0 2,620,369.00 Y Y Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11. Exhibit 99.1 Joint Filing Agreement by and among the reporting persons Opaleye Management Inc. /s/ James Silverman 05/22/2026 Opaleye, L.P. /s/ James Silverman 05/22/2026 James Silverman /s/ James Silverman 05/22/2026