X0202 SCHEDULE 13G/A 0001493152-25-023857 0001595855 XXXXXXXX LIVE 3 Ordinary Shares, par value NIS 1.00 per share. 02/13/2026 0001684693 Sol-Gel Technologies Ltd M8694L137 6 HaChoshlim St., Bldg. C, Herzliya L3 6701101 Rule 13d-1(c) Opaleye Management Inc. MA 0.00 460335.00 0.00 460335.00 460335.00 N 16.52 IA Opaleye, L.P. MA 0.00 450335.00 0.00 450335.00 450335.00 N 16.16 PN James Silverman X1 0.00 460335.00 0.00 460335.00 460335.00 N 16.52 IN Sol-Gel Technologies Ltd 6 HaChoshlim St., Bldg. C, Herzliya, ISRAEL, 6701101 This statement is filed by (i) Opaleye Management Inc. (the "Adviser"), (ii) Opaleye, L.P. (the "Fund") and (iii) James Silverman with respect to shares directly held by the Fund. The Adviser serves as investment adviser to the Fund. Mr. Silverman exercises control over the Adviser. Based on 2,786,158 Ordinary Shares outstanding as of December 31, 2025, as reported by Sol-Gel Technologies Ltd in its Annual Report on Form 20-F filed with the Securities and Exchange Commission. The filing of this statement should not be construed as an admission that any of the foregoing persons is, for the purposes of Section 13 of the Securities Exchange Act, the beneficial owner of the shares reported herein. One Boston Place, 26th Floor, Boston, MA 02108 Opaleye Management Inc. - Massachusetts Opaleye, L.P. - Massachusetts James Silverman - USA N IA HC 460,335.00 16.52 0 460,335.00 0 460,335.00 Y Y Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. Exhibit 99.1 Joint Filing Agreement by and among the reporting persons Opaleye Management Inc. /s/ James Silverman 03/23/2026 Opaleye, L.P. /s/ James Silverman 03/23/2026 James Silverman /s/ James Silverman 03/23/2026