SCHEDULE 13G/A 0001493152-26-007593 0001595855 XXXXXXXX LIVE 2 Common Stock, no par value 02/19/2026 0001655923 Alpha Cognition Inc. 02074J501 1452 Hughes Rd. Ste. 200, Grapevine TX 76051 Rule 13d-1(c) Opaleye Management Inc. MA 0.00 2193589.00 0.00 2193589.00 2193589.00 N 10.09 IA CO Includes shares held in a managed account over which the Adviser has shared voting and dispositive power. Opaleye, L.P. MA 0.00 2125000.00 0.00 2125000.00 2125000.00 N 9.77 PN Based on 21,742,104 Common Shares outstanding as reported by Alpha Cognition, Inc. in its Form 10-Q filed with the SEC on November 13, 2025. James Silverman X1 0.00 2193589.00 0.00 2193589.00 2193589.00 N 10.09 IN Adviser and Mr. Silverman may be deemed to beneficially own additional shares held in a Managed Account, beyond the Fund's direct holdings. Alpha Cognition Inc. 1452 Hughes Rd. Ste. 200, Grapevine, TX 76051 Opaleye Management Inc. Opaleye, L.P. James Silverman This statement is filed by (i) Opaleye Management Inc. (the "Adviser"), (ii) Opaleye, L.P. (the "Fund") and (iii) James Silverman with respect to shares directly held by the Fund and in a managed account. The Adviser serves as investment adviser to the Fund. Mr. Silverman exercises control over the Adviser. The filing of this statement should not be construed as an admission that any of the foregoing persons is, for the purposes of Section 13 of the Securities Exchange Act, the beneficial owner of the shares reported herein. One Boston Place, 26th Floor, Boston, MA 02108 Opaleye Management Inc. - Massachusetts Opaleye, L.P. - Massachusetts James Silverman - USA N IA 2,193,589.00 10.09% 0 2,193,589.00 0 2,193,589.00 Y Y Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. Exhibit 99.1 Joint Filing Agreement by and among the reporting persons Opaleye Management Inc. /s/ James Silverman 02/20/2026 Opaleye, L.P. /s/ James Silverman 02/20/2026 James Silverman /s/ James Silverman 02/20/2026