SCHEDULE 13G/A 0001493152-19-006391 0001595855 XXXXXXXX LIVE 6 Common Stock, par value $0.0001 per share 12/31/2024 0001393434 OCULAR THERAPEUTIX, INC 67576A100 24 Cosby Drive, BEDFORD MA 01730 Rule 13d-1(c) Opaleye Management Inc. MA 0.00 4342500.00 0.00 4342500.00 4342500.00 N 2.76 CO OCULAR THERAPEUTIX, INC 24 Cosby Drive, Bedford, MA 01730 Opaleye, L.P. One Boston Place, 26th Floor, Boston, MA 02108 USA Y 4,342,500 2.76% 0 4,342,500 0 4,342,500 N Y Y Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. Opaleye Management Inc. /s/ James Silverman 02/13/2025