<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/schedule13g" xmlns:com="http://www.sec.gov/edgar/common">
  <schemaVersion>X0202</schemaVersion>
<headerData>
    <submissionType>SCHEDULE 13G</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <!-- Field: Pseudo-Tag; ID: Name; Data: Weil Edward M Jr. -->
          <cik>0001490448</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>


    </filerInfo>
  </headerData>
  <formData>
    <coverPageHeader>
      <securitiesClassTitle>Class A Common Stock</securitiesClassTitle>
      <eventDateRequiresFilingThisStatement>07/07/2026</eventDateRequiresFilingThisStatement>
      <issuerInfo>
        <issuerCik>0001595527</issuerCik>
        <issuerName>American Strategic Investment Co.</issuerName>
        <issuerCusips>
          <issuerCusipNumber>649439304</issuerCusipNumber>
        </issuerCusips>
        <issuerPrincipalExecutiveOfficeAddress>
          <com:street1>222 Bellevue Avenue</com:street1>
          <com:city>Newport</com:city>
          <com:stateOrCountry>RI</com:stateOrCountry>
          <com:zipCode>02840</com:zipCode>
        </issuerPrincipalExecutiveOfficeAddress>
      </issuerInfo>
      <designateRulesPursuantThisScheduleFiled>
        <designateRulePursuantThisScheduleFiled>Rule 13d-1(c)</designateRulePursuantThisScheduleFiled>
      </designateRulesPursuantThisScheduleFiled>
    </coverPageHeader>
    <coverPageHeaderReportingPersonDetails>


      <reportingPersonName>Edward M. Weil, Jr.</reportingPersonName>
      <citizenshipOrOrganization>X1</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>109.00</soleVotingPower>
        <sharedVotingPower>0.00</sharedVotingPower>
        <soleDispositivePower>300109.00</soleDispositivePower>
        <sharedDispositivePower>0.00</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>300109.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
      <classPercent>9.49</classPercent>
      <typeOfReportingPerson>IN</typeOfReportingPerson>
      <comments>(1) Does not include 300,000 shares of Class A Common Stock subject to a voting agreement, pursuant to which Mr. Weil granted an irrevocable proxy to Bellevue Capital Partners, LLC ("Bellevue") to vote such shares in Bellevue's sole discretion. As such, Mr. Weil does not have voting control over these shares, but Mr. Weil retains full dispositive power over such shares.

(2) See Item 4.</comments>
    </coverPageHeaderReportingPersonDetails>
    <items>
      <item1>
        <issuerName>American Strategic Investment Co.</issuerName>
        <issuerPrincipalExecutiveOfficeAddress>222 Bellevue Avenue, Newport, Rhode Island 02840.</issuerPrincipalExecutiveOfficeAddress>
      </item1>
      <item2>
        <filingPersonName>Edward M. Weil, Jr.</filingPersonName>
        <principalBusinessOfficeOrResidenceAddress>650 Fifth Avenue, 30th Floor, New York, New York 10019</principalBusinessOfficeOrResidenceAddress>
        <citizenship>Mr. Weil is a citizen of the United States of America</citizenship>
      </item2>
      <item3>
        <notApplicableFlag>Y</notApplicableFlag>
      </item3>
      <item4>
        <amountBeneficiallyOwned>300,109</amountBeneficiallyOwned>
        <classPercent>9.49% (1)</classPercent>
        <numberOfSharesPersonHas>
          <solePowerOrDirectToVote>109 (2)</solePowerOrDirectToVote>
          <sharedPowerOrDirectToVote>0</sharedPowerOrDirectToVote>
          <solePowerOrDirectToDispose>300,109</solePowerOrDirectToDispose>
          <sharedPowerOrDirectToDispose>0

(1) Calculated on the basis of 3,163,632 shares of Class A Common Stock outstanding as of July 8, 2026.

(2) Does not include 300,000 shares of Class A Common Stock subject to a voting agreement, pursuant to which Mr. Weil granted an irrevocable proxy to Bellevue Capital Partners, LLC ("Bellevue") to vote such shares in Bellevue's sole discretion. As such, Mr. Weil does not have voting control over these shares, but Mr. Weil retains full dispositive power over such shares.</sharedPowerOrDirectToDispose>
        </numberOfSharesPersonHas>
      </item4>
      <item5>
        <notApplicableFlag>Y</notApplicableFlag>
      </item5>
      <item6>
        <notApplicableFlag>Y</notApplicableFlag>
      </item6>
      <item7>
        <notApplicableFlag>Y</notApplicableFlag>
      </item7>
      <item8>
        <notApplicableFlag>Y</notApplicableFlag>
      </item8>
      <item9>
        <notApplicableFlag>Y</notApplicableFlag>
      </item9>
      <item10>
        <notApplicableFlag>N</notApplicableFlag>
        <certifications>By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11.</certifications>
      </item10>
    </items>
    <signatureInformation>
      <reportingPersonName>Edward M. Weil, Jr.</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Edward M. Weil, Jr.</signature>
        <title>Edward M. Weil, Jr.</title>
        <date>07/14/2026</date>
      </signatureDetails>
    </signatureInformation>
  </formData>
</edgarSubmission>
