- Definition

The aggregate costs incurred (1) in a planned search or critical investigation aimed at discovery of new knowledge with the hope that such knowledge will be useful in developing a new product or service, a new process or technique, or in bringing about a significant improvement to an existing product or process; or (2) to translate research findings or other knowledge into a plan or design for a new product or process or for a significant improvement to an existing product or process whether intended for sale or the entity's use, during the reporting period charged to research and development projects, including the costs of developing computer software up to the point in time of achieving technological feasibility, and costs allocated in accounting for a business combination to in-process projects deemed to have no alternative future use.

+ References+ Details

Collaboration Agreements - Seattle Children's Research Institute - Additional Information (Detail) (USD $)	3 Months Ended		1 Months Ended	0 Months Ended	1 Months Ended
	Mar. 31, 2015	Mar. 31, 2014	Feb. 28, 2014	Apr. 01, 2015	Nov. 30, 2014
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Research and development expenses	$ 57,799,000us-gaap_ResearchAndDevelopmentExpense	$ 2,939,000us-gaap_ResearchAndDevelopmentExpense
Collaborative Arrangement [Member] \| Seattle Children's Research Institute [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Collaboration agreement, term			5 years
Sponsored research agreement amended expiration date	Apr. 01, 2020
Research and development expenses	200,000	0
Collaborative Arrangement [Member] \| Seattle Children's Research Institute [Member] \| Subsequent Event [Member] \| Minimum [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Additional research funding obligations				300,000
Collaborative Arrangement [Member] \| Research and Development Arrangement [Member] \| Seattle Children's Research Institute [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Aggregate research funding, committed			2,100,000
Collaborative Arrangement [Member] \| Clinical Trial [Member] \| Seattle Children's Research Institute [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Collaboration agreement, term	5 years
Collaborative Arrangement [Member] \| Clinical Trial [Member] \| Seattle Children's Research Institute [Member] \| Minimum [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Clinical trial funding committed amount					$ 4,100,000