Stock-based Compensation (Tables)

3 Months Ended

Mar. 31, 2025

Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]

Summary of Stock Options Activity

The following table summarizes stock option activity:

	Number of Shares			Weighted Average Exercise Price Per Share		Weighted Average Remaining Contractual Term (years)		Aggregate Intrinsic Value ($000s)
Outstanding at January 1, 2025		20,166,069		$	13.51		6.6	$	6,095
Granted		2,933,228		$	3.06
Exercised		—		$	—
Cancelled		(391,841	)	$	6.15
Outstanding at March 31, 2025		22,707,456		$	12.29		6.6	$	4,881
Vested and expected to vest at March 31, 2025		22,707,456		$	12.29		6.6	$	4,881
Vested and exercisable at March 31, 2025		15,684,916		$	15.93		5.6	$	4,880

Summary of Stock-based Compensation Expense by Award Type

Stock-based compensation expense by award type included within the unaudited condensed consolidated statements of operations and comprehensive loss was as follows:

	Three Months Ended March 31,
	2025		2024
Stock options	$	5,156	$	11,141
Restricted stock units		1,377		1,290
Performance-based restricted stock units		387		120
Employee stock purchase plan		31		35
Total stock-based compensation expense	$	6,951	$	12,586

Schedule of Stock-based Compensation Expense

Stock-based compensation expense is classified as follows:

	Three Months Ended March 31,
	2025		2024
Research and development expense	$	3,440	$	5,981
General and administrative expense		3,511		6,605
Total stock-based compensation expense	$	6,951	$	12,586

Restricted Stock Units

Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]

Summary of Restricted Stock Units

Below is the activity related to restricted stock units for the three months ended March 31, 2025.

	Number of Shares			Weighted Average Grant Date Fair Value
Outstanding at January 1, 2025		2,523,052		$	4.42
Granted		913,464		$	3.06
Released		(1,039,365	)	$	4.60
Cancelled		(108,388	)	$	4.23
Unvested at March 31, 2025		2,288,763		$	3.80

Performance-based Restricted Stock Units

Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]

Summary of Restricted Stock Units

The following table summarizes the activity related to performance-based restricted stock units:

	Number of Shares			Weighted Average Grant Date Fair Value
Outstanding at January 1, 2025		1,782,870		$	5.37
Granted		1,045,600		$	3.06
Released		(181,242	)	$	7.14
Cancelled		(181,243	)	$	7.14
Unvested at March 31, 2025		2,465,985		$	4.13