CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
OPERATING ACTIVITIES:
Net (loss) income	$ (2,923,105)	$ (613,245)	$ 183,944
Adjustments to reconcile Net (loss) income to Net cash provided by operating activities:
Depreciation and amortization	391,629	457,098	518,807
Share-based compensation	17,314	30,046	41,357
Amortization of debt issuance costs and discount	9,406	14,437	15,606
Deferred income taxes	(7,303)	(3,157)	(163,558)
Change in fair value of contingent consideration	408	(8,793)	16,353
Loss (gain) on extinguishment of debt	0	13,753	0
Acquired in-process research and development charges	68,700	25,120	33,329
Asset impairments	2,142,746	414,977	120,344
Non-cash reorganization items, net	89,197	0	0
Gain on sale of business and other assets	(26,183)	(4,516)	(16,353)
Other	2,776	0	0
Changes in assets and liabilities which provided (used) cash:
Accounts receivable	105,912	(82,052)	(45,792)
Inventories	(4,359)	48,978	(8,031)
Prepaid and other assets	80,350	(34,002)	(27,421)
Accounts payable, accrued expenses and other liabilities	321,055	84,391	(171,366)
Income taxes payable/receivable, net	650	68,015	(95,100)
Net cash provided by operating activities	269,193	411,050	402,119
INVESTING ACTIVITIES:
Capital expenditures, excluding capitalized interest	(99,722)	(77,929)	(69,971)
Capitalized interest payments	(3,140)	(2,721)	(2,892)
Proceeds from the U.S. Government Agreement	18,635	0	0
Acquisitions, including in-process research and development, net of cash and restricted cash acquired	(90,320)	(5,000)	(654,231)
Proceeds from sales and maturities of investments	0	0	92,763
Product acquisition costs and license fees	0	(4,177)	(2,000)
Proceeds from sale of business and other assets, net	41,400	30,283	6,737
Net cash used in investing activities	(133,147)	(59,544)	(629,594)
FINANCING ACTIVITIES:
Proceeds from issuance of notes, net	0	1,279,978	0
Proceeds from issuance of term loans, net	0	1,980,000	0
Repayments of notes	(180,342)	0	(57,649)
Repayments of term loans	(10,000)	(3,310,475)	(34,150)
Repayments of revolving debt	0	(22,800)	0
Adequate protection payments	(313,109)	0	0
Repayments of other indebtedness	(6,062)	(5,448)	(4,884)
Payments for debt issuance and extinguishment costs	0	(8,574)	0
Payments for contingent consideration	(2,462)	(4,010)	(3,848)
Payments of tax withholding for restricted shares	(1,898)	(14,774)	(8,036)
Proceeds from exercise of options	0	622	0
Net cash used in financing activities	(513,873)	(105,481)	(108,567)
Effect of foreign exchange rate	(4,242)	285	654
NET (DECREASE) INCREASE IN CASH, CASH EQUIVALENTS, RESTRICTED CASH AND RESTRICTED CASH EQUIVALENTS	(382,069)	246,310	(335,388)
CASH, CASH EQUIVALENTS, RESTRICTED CASH AND RESTRICTED CASH EQUIVALENTS, BEGINNING OF PERIOD	1,631,310	1,385,000	1,720,388
CASH, CASH EQUIVALENTS, RESTRICTED CASH AND RESTRICTED CASH EQUIVALENTS, END OF PERIOD	1,249,241	1,631,310	1,385,000
SUPPLEMENTAL INFORMATION:
Cash paid for interest, excluding capitalized interest and adequate protection payments	289,664	538,424	534,529
Cash paid for income taxes, gross	14,101	10,019	11,669
Cash refunds from income taxes, gross	3,092	57,801	31,897
SCHEDULE OF NONCASH INVESTING AND FINANCING ACTIVITIES:
Acquisitions, including in-process research and development, accrued in the period but not yet paid	$ 0	$ 20,120	$ 0