Exhibit 10.224

SUPPLEMENTAL INDENTURE

SUPPLEMENTAL INDENTURE (this “Supplemental Indenture”), dated as of February 3, 2015, among Auxilium International Holdings, Inc., a Delaware corporation, Slate Pharmaceuticals, Inc., a Delaware corporation, Timm Medical Technologies, Inc., a Delaware corporation, Actient Holdings LLC, a Delaware limited liability company, Actient Pharmaceuticals LLC, a Delaware limited liability company, Actient Therapeutics LLC, a Delaware limited liability company, Auxilium US Holdings, LLC, a Delaware limited liability company, Auxilium Pharmaceuticals, Inc., a Delaware corporation, 70 Maple Avenue, LLC, a Delaware limited liability company, Timm Medical Holdings, LLC, a Delaware limited liability company, Auxilium UK LTD, a company incorporated in England and Wales with registration number 4054079, Auxilium Bermuda Unlimited, a Bermuda exempted company incorporated with unlimited liability and Endo Finance II Limited, a limited liability company incorporated under the laws of Ireland (collectively, the “Guaranteeing Subsidiaries”), subsidiaries of Endo Limited, a private limited company incorporated under the laws of Ireland (the “Company”), the Issuers, the other Guarantors (both, as defined in the Indenture referred to below) and Wells Fargo Bank, National Association, as trustee under the Indenture referred to below (the “Trustee”).

W I T N E S S E T H

WHEREAS, Endo Finance LLC, a Delaware limited liability company, and Endo Finco Inc., a Delaware corporation, have heretofore executed and delivered to the Trustee an indenture, dated as of May 6, 2014, as supplemented by a supplemental indenture, dated as of May 28, 2014, a supplemental indenture, dated as of July 10, 2014, a supplemental indenture, dated as of August 11, 2014, and a supplemental indenture, dated as of December 22, 2014, in each case, among the Issuers, the Guarantors party thereto and the Trustee (as so supplemented, the “Indenture”), providing for the issuance of 7.00% Senior Notes due 2019 (the “Notes”);

WHEREAS, the Indenture provides that under certain circumstances the Guaranteeing Subsidiaries shall execute and deliver to the Trustee a supplemental indenture pursuant to which the Guaranteeing Subsidiaries shall unconditionally guarantee all of the Issuers’ Obligations under the Notes and the Indenture on the terms and conditions set forth herein (the “Note Guarantee”);

WHEREAS, this Supplemental Indenture has not resulted in a material modification of the Notes for Foreign Account Tax Compliance Act purposes; and

WHEREAS, pursuant to Section 9.01 of the Indenture, the Trustee is authorized to execute and deliver this Supplemental Indenture.

NOW, THEREFORE, in consideration of the foregoing and for other good and valuable consideration, the receipt of which is hereby acknowledged, the Guaranteeing Subsidiaries and the Trustee mutually covenant and agree for the equal and ratable benefit of the Holders of the Notes as follows:

1.    CAPITALIZED TERMS. Capitalized terms used herein without definition shall have the meanings assigned to them in the Indenture.

2.    AGREEMENT TO GUARANTEE. Each of the Guaranteeing Subsidiaries hereby agrees to provide an unconditional Guarantee on the terms and subject to the conditions set forth in the Note Guarantee and in the Indenture including but not limited to Article 10 thereof.

3.    NO RECOURSE AGAINST OTHERS. No director, officer, employee, incorporator or stockholder of the Issuers or any Guarantor, as such, will have any liability for any

Exhibit 10.224

obligations of the Issuers or the Guarantors under the Notes, the Indenture, this Supplemental Indenture, the Note Guarantees or for any claim based on, in respect of, or by reason of, such obligations or their creation. Each Holder of Notes by accepting a Note waives and releases all such liability. The waiver and release are part of the consideration for issuance of the Notes. The waiver may not be effective to waive liabilities under the federal securities laws.

4.    NEW YORK LAW TO GOVERN; WAIVER OF JURY TRIAL. THIS SUPPLEMENTAL INDENTURE SHALL BE GOVERNED BY, AND CONSTRUED IN ACCORDANCE WITH THE LAWS OF THE STATE OF NEW YORK. EACH OF THE ISSUERS AND THE GUARANTORS CONSENTS AND IRREVOCABLY SUBMITS TO THE JURISDICTION OF ANY NEW YORK STATE OR U.S. FEDERAL COURT LOCATED IN THE BOROUGH OF MANHATTAN, CITY OF NEW YORK, COUNTY OF NEW YORK, STATE OF NEW YORK IN RELATION TO ANY LEGAL ACTION OR PROCEEDING (I) ARISING OUT OF, RELATING TO OR IN CONNECTION WITH THIS INDENTURE, AS SUPPLEMENTED, THE NOTES, THE GUARANTEES AND ANY RELATED DOCUMENTS AND/OR (II) ARISING UNDER ANY U.S. FEDERAL OR U.S. STATE SECURITIES LAWS IN RESPECT OF THE NOTES, THE GUARANTEES AND ANY SECURITIES ISSUED PURSUANT TO THE TERMS OF THE INDENTURE, AS SUPPLEMENTED. EACH OF THE ISSUERS AND THE GUARANTORS WAIVES ANY OBJECTION TO PROCEEDINGS IN ANY SUCH COURTS, WHETHER ON THE GROUND OF VENUE OR ON THE GROUND THAT THE PROCEEDINGS HAVE BEEN BROUGHT IN AN INCONVENIENT FORUM. EACH OF THE ISSUERS AND THE GUARANTORS, TO THE EXTENT ORGANIZED OUTSIDE OF THE UNITED STATES, SHALL APPOINT CT CORPORATION SYSTEM, 111 EIGHTH AVENUE, 13TH FLOOR, NEW YORK, NY 10011, AS ITS AGENT FOR SERVICE OF PROCESS IN ANY SUCH SUIT, ACTION OR PROCEEDING AND AGREES THAT SERVICE OF PROCESS UPON SAID AUTHORIZED AGENT SHALL BE DEEMED IN EVERY RESPECT EFFECTIVE SERVICE OF PROCESS UPON IT IN ANY SUCH SUIT, ACTION OR PROCEEDING. EACH OF THE ISSUERS AND THE GUARANTORS AGREES TO DELIVER, UPON THE EXECUTION AND DELIVERY OF THIS SUPPLEMENTAL INDENTURE, A WRITTEN ACCEPTANCE BY SUCH AGENT OF ITS APPOINTMENT AS SUCH AGENT. EACH OF THE ISSUERS AND THE GUARANTORS, TO THE EXTENT ORGANIZED OUTSIDE OF THE UNITED STATES, FURTHER AGREES TO TAKE ANY AND ALL ACTION, INCLUDING THE FILING OF ANY AND ALL SUCH DOCUMENTS AND INSTRUMENTS, AS MAY BE REASONABLY NECESSARY TO CONTINUE SUCH DESIGNATION AND APPOINTMENT OF CT CORPORATION SYSTEM IN FULL FORCE AND EFFECT FOR SO LONG AS THE INDENTURE, AS SUPPLEMENTED, REMAINS IN FORCE. EACH OF THE ISSUERS, THE TRUSTEE AND THE GUARANTORS HEREBY IRREVOCABLY WAIVES, TO THE FULLEST EXTENT PERMITTED BY APPLICABLE LAW, ANY AND ALL RIGHT TO TRIAL BY JURY IN ANY LEGAL PROCEEDING ARISING OUT OF OR RELATING TO THIS SUPPLEMENTAL INDENTURE, THE NOTES OR THE TRANSACTIONS CONTEMPLATED HEREBY.

5.    COUNTERPARTS. The parties may sign any number of copies of this Supplemental Indenture. Each signed copy (which may be provided via facsimile or other electronic transmission) shall be an original, but all of them together represent the same agreement.

6.    EFFECT OF HEADINGS. The Section headings herein are for convenience only and shall not affect the construction hereof.

7.    THE TRUSTEE. The Trustee shall not be responsible in any manner whatsoever for or in respect of the validity or sufficiency of this Supplemental Indenture or for or in respect of the recitals contained herein, all of which recitals are made solely by the Guaranteeing Subsidiaries and the Issuers.

Exhibit 10.224

IN WITNESS WHEREOF, the parties hereto have caused this Supplemental Indenture to be duly executed and attested, all as of the date first above written.

AUXILIUM INTERNATIONAL HOLDINGS, INC.

as a Guaranteeing Subsidiary

By:	/s/ Deanna Voss
Name:	Deanna Voss
Title:	Assistant Secretary

SLATE PHARMACEUTICALS, INC.

as a Guaranteeing Subsidiary

By:	/s/ Deanna Voss
Name:	Deanna Voss
Title:	Assistant Secretary

TIMM MEDICAL TECHNOLOGIES, INC.

as a Guaranteeing Subsidiary

By:	/s/ Deanna Voss
Name:	Deanna Voss
Title:	Assistant Secretary

ACTIENT HOLDINGS LLC

as a Guaranteeing Subsidiary

By:	AUXILIUM PHARMACEUTICALS, INC.,
	its manager

By:	/s/ Deanna Voss
Name:	Deanna Voss
Title:	Assistant Secretary

ACTIENT PHARMACEUTICALS LLC

as a Guaranteeing Subsidiary

[Signature Page to 7.00% Senior Notes due 2019 Supplemental Indenture]

Exhibit 10.224

By:	ACTIENT HOLDINGS LLC,
	its manager

By:	AUXILIUM PHARMACEUTICALS, INC.,
	its manager

By:	/s/ Deanna Voss
Name:	Deanna Voss
Title:	Assistant Secretary

ACTIENT THERAPEUTICS LLC

as a Guaranteeing Subsidiary

By:	/s/ Deanna Voss
Name:	Deanna Voss
Title:	Assistant Secretary

AUXILIUM US HOLDINGS LLC,

as a Guaranteeing Subsidiary

By:	AUXILIUM PHARMACEUTICALS, INC.,
	its manager

By:	/s/ Deanna Voss
Name:	Deanna Voss
Title:	Assistant Secretary

AUXILIUM PHARMACEUTICALS, INC.,

as a Guaranteeing Subsidiary

By:	/s/ Deanna Voss
Name:	Deanna Voss
Title:	Assistant Secretary

[Signature Page to 7.00% Senior Notes due 2019 Supplemental Indenture]

Exhibit 10.224

70 MAPLE AVENUE, LLC

as a Guaranteeing Subsidiary

By:	ACTIENT PHARMACEUTICALS LLC,
	its manager

By:	ACTIENT HOLDINGS LLC,
	its manager

By:	AUXILIUM PHARMACEUTICALS LLC,
	its manager

By:	/s/ Deanna Voss
Name:	Deanna Voss
Title:	Assistant Secretary

TIMM MEDICAL HOLDINGS, LLC

as a Guaranteeing Subsidiary

By:	ACTIENT PHARMACEUTICALS LLC,
	its manager

By:	ACTIENT HOLDINGS LLC,
	its manager

By:	AUXILIUM PHARMACEUTICALS LLC,
	its manager

By:	/s/ Deanna Voss
Name:	Deanna Voss
Title:	Assistant Secretary

[Signature Page to 7.00% Senior Notes due 2019 Supplemental Indenture]

Exhibit 10.224

AUXILIUM UK LTD

as a Guaranteeing Subsidiary

By:	/s/ Orla Dunlea
Name:	Orla Dunlea
Title:	Director

[Signature Page to 7.00% Senior Notes due 2019 Supplemental Indenture]

Exhibit 10.224

AUXILIUM BERMUDA UNLIMITED

as a Guaranteeing Subsidiary

By:	/s/ Susan Hall
Name:	Susan Hall
Title:	Director

[Signature Page to 7.00% Senior Notes due 2019 Supplemental Indenture]

Exhibit 10.224

ENDO FINANCE II LIMITED

as a Guaranteeing Subsidiary

By:	/s/ Orla Dunlea
Name:	Orla Dunlea
Title:	Director

[Signature Page to 7.00% Senior Notes due 2019 Supplemental Indenture]

Exhibit 10.224

ENDO FINANCE LLC

  as an Issuer

    by ENDO LUXEMBOURG FINANCECOMPANY I

        S.À R.L., its sole member

By:	/s/ John D. Boyle
Name:	John D. Boyle
Title:	A Manager

By:	/s/ Joost Tulkens
Name:	Joost Tulkens
Title:	B Manager

[Signature Page to 7.00% Senior Notes due 2019 Supplemental Indenture]

Exhibit 10.224

ENDO FINCO INC.

   as an Issuer

By:	/s/ Deanna Voss
Name:	Deanna Voss
Title:	Secretary

[Signature Page to 7.00% Senior Notes due 2019 Supplemental Indenture]

Exhibit 10.224

ENDO LLC

  ENDO U.S. INC.

    each, as a Guarantor

By:	/s/ Deanna Voss
Name:	Deanna Voss
Title:	Secretary

[Signature Page to 7.00% Senior Notes due 2019 Supplemental Indenture]

Exhibit 10.224

ENDO HEALTH SOLUTIONS INC.

ENDO PHARMACEUTICALS INC.

ENDO PHARMACEUTICALS SOLUTIONS INC.

ENDO PHARMACEUTICALS VALERA INC

GENERICS INTERNATIONAL (US PARENT), INC.

GENERICS INTERNATIONAL (US MIDCO), INC.

GENERICS INTERNATIONAL (US HOLDCO), INC.

GENERICS INTERNATIONAL (US), INC.

AMERICAN MEDICAL SYSTEMS HOLDINGS, INC.

AMERICAN MEDICAL SYSTEMS, INC.

AMS RESEARCH CORPORATION

AMS SALES CORPORATION

LASERSCOPE

each, as a Guarantor

By:	/s/ Deanna Voss
Name:	Deanna Voss
Title:	Assistant Secretary

[Signature Page to 7.00% Senior Notes due 2019 Supplemental Indenture]

Exhibit 10.224

GENERICS BIDCO I, LLC

VINTAGE PHARMACEUTICALS, LLC

GENERICS BIDCO II, LLC

MOORES MILL PROPERTIES LLC

WOOD PARK PROPERTIES LLC

QUARTZ SPECIALTY PHARMACEUTICALS, LLC

   each, as a Guarantor

   by GENERICS INTERNATIONAL (US), INC.,

   its manager

By:	/s/ Deanna Voss
Name:	Deanna Voss
Title:	Assistant Secretary

[Signature Page to 7.00% Senior Notes due 2019 Supplemental Indenture]

Exhibit 10.224

LEDGEMONT ROYALTY SUB LLC

   as a Guarantor

   by ENDO PHARMACEUTICALS SOLUTIONS INC.,

   its manager

By:	/s/ Deanna Voss
Name:	Deanna Voss
Title:	Assistant Secretary

[Signature Page to 7.00% Senior Notes due 2019 Supplemental Indenture]

Exhibit 10.224

BOCA PHARMACAL, LLC, as a

Guaranteeing Subsidiary

    by GENERICS INTERNATIONAL (US), INC., its

     sole member

By:	/s/ Deanna Voss
	Name: Deanna Voss
	Title: Assistant Secretary

DAVA INTERNATIONAL, LLC, as a

Guaranteeing Subsidiary

    by DAVA PHARMACEUTICALS, INC., its

     sole member

By:	/s/ Deanna Voss
	Name: Deanna Voss
	Title: Assistant Secretary

DAVA CAPITAL MANAGEMENT, INC., as a

Guaranteeing Subsidiary

By:	/s/ Deanna Voss
	Name: Deanna Voss
	Title: Assistant Secretary

[Signature Page to 7.00% Senior Notes due 2019 Supplemental Indenture]

Exhibit 10.224

ENDO LIMITED

   as a Guarantor

By:	/s/ Orla Dunlea
	Orla Dunlea
	Title: Director

ENDO VENTURES LIMITED

   as a Guarantor

By:	/s/ Orla Dunlea
	Orla Dunlea
	Title: Director

ENDO MANAGEMENT LIMITED

   as a Guarantor

By:	/s/ Orla Dunlea
	Orla Dunlea
	Title: Director

ENDO FINANCE LIMITED

   as a Guarantor

By:	/s/ Orla Dunlea
	Orla Dunlea
	Title: Director

[Signature Page to 7.00% Senior Notes due 2019 Supplemental Indenture]

Exhibit 10.224

ENDO LUXEMBOURG HOLDING COMPANY S.À R.L.

   as a Guarantor

By:	/s/ John D. Boyle
Name:	John D. Boyle
Title:	A Manager

By:	/s/ Joost Tulkens
Name:	Joost Tulkens
Title:	B Manager

ENDO LUXEMBOURG FINANCE COMPANY S.À R.L.

   as a Guarantor

By:	/s/ John D. Boyle
Name:	John D. Boyle
Title:	A Manager

By:	/s/ Joost Tulkens
Name:	Joost Tulkens
Title:	B Manager

ENDO LUXEMBOURG FINANCE COMPANY S.À R.L.

   as a Guarantor

By:	/s/ John D. Boyle
Name:	John D. Boyle
Title:	A Manager

By:	/s/ Joost Tulkens
Name:	Joost Tulkens
Title:	B Manager

[Signature Page to 7.00% Senior Notes due 2019 Supplemental Indenture]

Exhibit 10.224

PALADIN LABS CANADIAN HOLDING INC.

   as a Guarantor

By:	/s/ Mark Beaudet
Name:	Mark Beaudet
Title:	President

PALADIN LABS INC.

   as a Guarantor

By:	/s/ Mark Beaudet
Name:	Mark Beaudet
Title:	President

[Signature Page to 7.00% Senior Notes due 2019 Supplemental Indenture]

Exhibit 10.224

ENDO VENTURES BERMUDA LIMITED, as a

Guarantor

By:	/s/ Susan Hall
	Name: Susan Hall
	Title: Director

[Signature Page to 7.00% Senior Notes due 2019 Supplemental Indenture]

Exhibit 10.224

ENDO NETHERLANDS B.V., as a Guarantor

By:	/s/ Blaine T. Davis
	Name: Blaine T. Davis
	Title: Managing Director A

By:	/s/ Gert Jan Rietberg
	Name: Gert Jan Rietberg
	Title: Managing Director B

[Signature Page to 7.00% Senior Notes due 2019 Supplemental Indenture]

Exhibit 10.224

WELLS FARGO BANK, NATIONAL ASSOCIATION,

as Trustee

By:	/s/ Yana Kislenko
	Name: Yana Kislenko
	Title: Vice President

[Signature Page to 7.00% Senior Notes due 2019 Supplemental Indenture]