X0206 3 2014-01-30 0 0001429560 TREVENA INC TRVN 0001591474 Cuca Roberto C/O TREVENA, INC. 1018 WEST 8TH AVENUE, SUITE A KING OF PRUSSIA PA 19406 0 1 0 0 Sr. VP and CFO Common Stock 0 D Employee Stock Option (Right to Buy) 7.44 2023-09-03 Common Stock 197449 D These shares shall vest and become exercisable as to 1/8th of the total number of shares of stock subject to the option on March 3, 2014. Thereafter, on a quarterly basis (i.e., every three months) measured from March 3, 2014, the option shall become vested with respect to an additional 1/16 of the total number of shares of stock subject to the option, until such time as the option is vested with respect to all of the shares of stock subject to the option. /s/Derek Colla, Attorney-in-Fact for Roberto Cuca 2014-01-30