X0306 4 2022-02-28 false 0001517022 Akebia Therapeutics, Inc. AKBA 0001591467 Butler John P. C/O AKEBIA THERAPEUTICS, INC. 245 FIRST STREET CAMBRIDGE MA 02142 true true false false CEO and President Common Stock 2022-02-28 4 S false 25053.00 2.1548 D 1164095.00 D Common Stock 2022-02-28 4 A false 293125.00 0.00 A 1457220.00 D Common Stock 2022-03-01 4 S false 24811.00 2.1707 D 1432409.00 D Common Stock 2022-03-01 4 S false 25031.00 2.1707 D 1407378.00 D Common Stock 2022-03-01 4 S false 4131.00 2.1707 D 1403247.00 D Common Stock 59928.00 I Held by Dorothy Butler 2019 GRAT Common Stock 100000.00 I Held By Dorothy Butler GRAT November 2019 Common Stock 59928.00 I Held by John Butler 2019 GRAT Common Stock 100000.00 I Held By John Butler GRAT November 2019 Employee Stock Option (Right to buy) 2.16 2022-02-28 4 A false 739700.00 0.00 A 2032-02-28 Common Stock 739700.00 739700.00 D This sale was made automatically by the Issuer to cover tax withholding obligations in connection with the vesting and settlement of one-third of the reporting person's restricted stock units granted on February 26, 2021. Includes: (i) the 1,248 shares of common stock that were described in the amendment on Form 4/A filed by the reporting person with the SEC on February 18, 2022, (ii) 1,500 shares of the Issuer's common stock purchased on each of June 30, 2021 and December 31, 2021, each under the Issuer's 2014 Amended and Restated Employee Stock Purchase Plan, and (iii) 32,747 shares of common stock that represent a change from indirect to direct ownership of shares previously reported as beneficially owned by the reporting person. The restricted stock units were granted by the Issuer pursuant to its 2014 Incentive Plan, as amended. One-third of the restricted stock units will vest on each of the first, second and third anniversaries of the grant date, subject to the reporting person's continued service with the Issuer on each vesting date. This sale was made automatically by the Issuer to cover tax withholding obligations in connection with the vesting and settlement of one-third of the reporting person's restricted stock units granted on February 28, 2020. This sale was made automatically by the Issuer to cover tax withholding obligations in connection with the vesting and settlement of one-third of the reporting person's restricted stock units granted on February 28, 2019. This sale was made automatically by the Issuer to cover tax withholding obligations in connection with the vesting and settlement of one-third of the performance-based restricted stock units that were previously reported for the Reporting Person on a Form 4 filed on March 18, 2021. The options were granted by the Issuer pursuant to its 2014 Incentive Plan, as amended. The options will vest over four years: 25% of the options will vest on the first anniversary of the grant date with the remaining 75% vesting in equal quarterly installments thereafter, subject to the reporting person's continued service with the Issuer on each vesting date. /s/ Carolyn Rucci, attorney-in-fact for John P. Butler 2022-03-02