X0306 5 2019-12-31 0 0 0 0001517022 Akebia Therapeutics, Inc. AKBA 0001591467 Butler John P. C/O AKEBIA THERAPEUTICS, INC. 245 FIRST STREET CAMBRIDGE MA 02142 1 1 0 0 CEO and President Common Stock 789232 D Common Stock 50000 I Held by John Butler GRAT (November 2019) Common Stock 50000 I Held by Dorothy Butler GRAT (November 2019) Common Stock 31047 I Held by Dorothy Butler Revocable Trust 2007 Common Stock 31047 I Held by John Butler Revocable Trust 2007 Common Stock 59928 I Held by John Butler 2019 GRAT Common Stock 59928 I Held by Dorothy Butler 2019 GRAT Reflects the transfer of 100,000 shares of the Issuer's common stock which were previously reported as directly beneficially owned but were contributed to two grantor retained annuity trusts on November 22, 2019. The holdings of these trusts are reported in Table I of this form. Includes 1,500 shares of the Issuer's common stock purchased under the Issuer's 2014 Amended and Restated Employee Stock Purchase Plan on December 31, 2019. /s/ Nicole R. Hadas, attorney-in-fact for John P. Butler 2020-02-14