X0508 4 2025-03-04 0001326732 Xencor Inc XNCR 0001591313 Desjarlais John R C/O XENCOR, INC. 465 N HALSTEAD STREET, SUITE 200 PASADENA CA 91107 1 SR. VICE PRESIDENT & CSO 0 Common Stock 2025-03-04 4 A 0 29851 0 A 246271 D Stock Option (Right to Buy) 14.15 2025-03-04 4 A 0 89552 0 A 2035-03-04 Common Stock 89552 89552 D Represents restricted stock units that vest as follows: 1/3 of the shares vest on the first, second and third anniversaries of the date of grant, subject to the Reporting Person's continuous service to the Issuer on and through each applicable vesting date, inclusive. 25% of the shares subject to the option shall vest on the one year anniversary of March 4, 2025 (the "Vesting Commencement Date") and 1/48th of the shares shall vest monthly thereafter, such that the option shall be fully vested on the four year anniversary of the Vesting Commencement Date, subject to the Reporting Person's continuous service to the Issuer on and through each applicable vesting date, inclusive. /s/ Celia E. Eckert, Attorney-in-Fact 2025-03-05