X0306 4 2018-02-05 0001178711 Paratek Pharmaceuticals, Inc. PRTK 0001591113 Radie Robert S C/O PARATEK PHARMACEUTICALS, INC. 75 PARK PLAZA, 4TH FLOOR BOSTON MA 02116 1 0 0 0 Common Stock 2018-02-05 4 S 0 3000 14.22 D 3000 D Sale of shares to cover personal income tax obligations upon vesting of restricted stock unit award, pursuant to Rule 10b5-1 trading plan. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $14.00 to $14.43, inclusive. The Reporting Person undertakes to provide to Paratek Pharmaceuticals, Inc., any security holder of Paratek Pharmaceuticals, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range. /s/ William M. Haskel, Attorney-in-Fact for Robert S. Radie 2018-02-07