Liability Related to Sale of Future Royalties - Additional Information (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Liability Related To Sale Of Future Royalties [Line Items]
Repurchase of call option amount	$ 300,000
Interest expense	6,130	$ 6,702
November 7, 2024
Liability Related To Sale Of Future Royalties [Line Items]
Repurchase of call option amount, before exercised	1,000
HCR [Member]
Liability Related To Sale Of Future Royalties [Line Items]
Proceeds from Royalties Received	4,000
Deferred Transaction Cost	3,500
Interest expense	$ 192,500
Interest Rate, Effective Percentage	14.80%
HCR [Member] | Other Noncurrent Liabilities
Liability Related To Sale Of Future Royalties [Line Items]
Proceeds from sale of future royalties	$ 196,000
HCR [Member] | November 7, 2024
Liability Related To Sale Of Future Royalties [Line Items]
Royalty Payment Cap Amount	260,000
HCR [Member] | November 8, 2024
Liability Related To Sale Of Future Royalties [Line Items]
Royalty Payment Cap Amount	300,000
HCR [Member] | Royalty Agreements
Liability Related To Sale Of Future Royalties [Line Items]
Purchase Agreement	$ 200,000