Consolidated Statements of Operations and Comprehensive Loss - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Revenues
Revenues	$ 22,218	$ 18,884
Operating Expenses
Cost of revenues	15,717	4,851
Research and development	55,627	39,722
General and administrative	22,318	17,838
Credit losses and other	83	515
Total operating expenses	93,745	62,926
Loss from operations	(71,527)	(44,042)
Other Income (Expense)
Interest income from licensing	94	29
Investment income	799	580
Interest expense	(6,130)	(6,702)
Total other income (expense)	(5,237)	(6,093)
Loss before income taxes	(76,764)	(50,135)
Income Tax Benefit (Expense)	41	(4)
Net loss	(76,723)	(50,139)
Other Comprehensive Loss
Unrealized loss on available-for-sale securities, net	(9,381)	(1,008)
Total other comprehensive loss	(9,381)	(1,008)
Comprehensive loss	$ (86,104)	$ (51,147)
Net loss per share, basic and diluted	$ (1.79)	$ (1.20)
Weighted-average common shares outstanding, basic and diluted	42,944	41,819
License and royalty [Member]
Revenues
Revenues	$ 22,218	$ 18,884