Income Taxes - Components of Net Deferred Tax Assets (Detail) - USD ($) $ in Thousands	Dec. 31, 2021	Dec. 31, 2020
Deferred tax assets:
Net operating loss carryforwards	$ 3,981	$ 14,683
Research and development tax credits	45,576	47,970
Stock-based compensation	18,303	15,644
Lease liabilities	23,430	21,961
Liability related sale of future royalties	43,234	62,089
Accruals and other	6,230	7,370
Total deferred tax assets before valuation allowance	140,754	169,717
Valuation allowance	(110,756)	(142,907)
Total deferred tax assets	29,998	26,810
Deferred tax liabilities:
Unrealized gains on marketable securities		(163)
Right-of-use assets	(16,363)	(21,094)
Depreciation and amortization	(13,635)	(5,155)
Other		(398)
Total deferred tax liabilities	$ (29,998)	$ (26,810)