Income Taxes - Schedule of Reconciliation of Effective Income Tax Expense (Benefit) (Detail) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Income Tax Disclosure [Abstract]
Federal income tax expense (benefit) at statutory rate	$ 29,662	$ (22,263)	$ (20,473)
State income tax expense (benefit), net of federal tax effect	9,183	(11,495)	(15,323)
Research and development credits	(10,059)	(7,793)	(11,075)
Stock-based compensation	755	587	(2,134)
Executive compensation	1,511	202
Other non-deductible expenses and reconciling items	329	684	144
Change in corporate tax rates	14,772	109	130
Change in valuation allowance	(32,746)	45,209	45,976
Total income tax expense (benefit)	$ 13,407	$ 5,240	$ (2,755)