License and Collaboration Agreements -Schedule of AbbVie Collaboration Agreement (Detail) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
License Revenue [Line Items]
Total license and royalty revenue	$ 470,347	$ 154,567	$ 35,233
Abb Vie Collaboration And License Agreement
License Revenue [Line Items]
Total license and royalty revenue	370,000
Reduction of research and development expense for costs reimbursable by AbbVie	$ 5,866