Fair Value of Financial Instruments - Additional Information (Detail) € in Millions	12 Months Ended
	Dec. 31, 2021 USD ($)	Dec. 31, 2021 EUR (€)	Dec. 31, 2020 USD ($)	Dec. 31, 2019 USD ($)
Fair Value Liabilities Measured On Recurring Basis Unobservable Input Reconciliation [Line Items]
Non-marketable equity securities			$ 1,100,000
Remeasurements or impairment losses on non-marketable equity securities	$ 0		$ 0	$ 0
Uni Qure N V
Fair Value Liabilities Measured On Recurring Basis Unobservable Input Reconciliation [Line Items]
Proceeds From Acquiring Business	5,600,000	€ 4.8
Additional Proceeds From Acquiring Business	600,000	0.5
Realized Gain	5,200,000
Revenue Recognition, Milestone Method, Revenue Recognized	$ 42,100,000	€ 37.1