Consolidated Statements of Operations and Comprehensive Income (Loss) - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Revenues
Revenues	$ 470,347	$ 154,567	$ 35,233
Operating Expenses
Cost of revenues	51,833	35,714	8,241
Research and development	181,437	166,294	124,185
General and administrative	79,333	63,817	51,815
Credit losses (recoveries) and other	(2,236)	7,975	(10)
Total operating expenses	310,367	273,800	184,231
Income (loss) from operations	159,980	(119,233)	(148,998)
Other Income (Expense)
Interest income from licensing	719	4,271	2,951
Investment income	6,825	9,723	48,559
Interest expense	(26,277)	(771)
Total other income (expense)	(18,733)	13,223	51,510
Income (loss) before income taxes	141,247	(106,010)	(97,488)
Income Tax Benefit (Expense)	(13,407)	(5,240)	2,755
Net income (loss)	127,840	(111,250)	(94,733)
Other Comprehensive Income (Loss)
Unrealized gain (loss) on available-for-sale securities, net	(2,209)	(565)	885
Total other comprehensive income (loss)	(2,209)	(565)	885
Comprehensive income (loss)	$ 125,631	$ (111,815)	$ (93,848)
Net income (loss) per share:
Basic	$ 3.01	$ (2.98)	$ (2.58)
Diluted	$ 2.91	$ (2.98)	$ (2.58)
Weighted-average common shares outstanding:
Basic	42,438	37,281	36,690
Diluted	43,913	37,281	36,690
License and royalty [Member]
Revenues
Revenues	$ 470,347	$ 154,567	$ 35,233