Consolidated Statements of Operations and Comprehensive Loss - USD ($) shares in Thousands, $ in Thousands	3 Months Ended
	Mar. 31, 2021	Mar. 31, 2020
Revenues
Revenues	$ 18,884	$ 17,644
Operating Expenses
Cost of revenues	4,851	3,409
Research and development	39,722	37,035
General and administrative	17,838	14,833
Provision for credit losses and other	515	67
Total operating expenses	62,926	55,344
Loss from operations	(44,042)	(37,700)
Other Income (Expense)
Interest income from licensing	29	848
Investment income (loss)	580	(3,186)
Interest expense	(6,702)
Total other income (expense)	(6,093)	(2,338)
Loss before income taxes	(50,135)	(40,038)
Income Tax Expense	(4)
Net loss	(50,139)	(40,038)
Other Comprehensive Loss
Unrealized loss on available-for-sale securities, net	(1,008)	(785)
Total other comprehensive loss	(1,008)	(785)
Comprehensive loss	$ (51,147)	$ (40,823)
Net loss per share, basic and diluted	$ (1.20)	$ (1.08)
Weighted-average common shares outstanding, basic and diluted	41,819	37,104
License and royalty [Member]
Revenues
Revenues	$ 18,884	$ 17,644