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Summary of Significant Accounting Policies - Additional Information (Detail) - USD ($)
$ in Thousands
3 Months Ended 6 Months Ended
Jun. 30, 2018
Jun. 30, 2017
Jun. 30, 2018
Jun. 30, 2017
Jan. 01, 2018
Dec. 31, 2017
Significant Accounting Policies [Line Items]            
Percentage of ownership interest 20.00%   20.00%      
Accumulated deficit $ (68,120)   $ (68,120)     $ (187,756)
License revenue 40,031 $ 6,562 172,422 $ 7,017    
Interest income from licensing 6,898   8,253      
License [Member]            
Significant Accounting Policies [Line Items]            
License revenue 40,031 $ 6,555 172,422 $ 7,010    
ASU 2014-09 [Member]            
Significant Accounting Policies [Line Items]            
Accumulated deficit         $ (182,953)  
ASU 2014-09 [Member] | AveXis, Inc. [Member]            
Significant Accounting Policies [Line Items]            
Payments due from related party 30,000   $ 30,000      
Consideration payment due period one     2019-01      
Consideration payment due period two     2020-01      
Interest income from licensing 6,800   $ 8,000      
ASU 2014-09 [Member] | AveXis, Inc. [Member] | License [Member]            
Significant Accounting Policies [Line Items]            
License revenue 40,000   172,100      
Reduction in Accumulated Deficit [Member] | ASU 2014-09 [Member]            
Significant Accounting Policies [Line Items]            
Accumulated deficit 3,692   3,692   $ 4,803  
Reduction in Accumulated Deficit [Member] | ASU 2014-09 [Member] | License [Member]            
Significant Accounting Policies [Line Items]            
License revenue (61,244)   (9,529)      
Results Without Adoption of Topic 606 | ASU 2014-09 [Member]            
Significant Accounting Policies [Line Items]            
Accumulated deficit (71,812)   (71,812)      
Results Without Adoption of Topic 606 | ASU 2014-09 [Member] | License [Member]            
Significant Accounting Policies [Line Items]            
License revenue 101,275   181,951      
Results Without Adoption of Topic 606 | ASU 2014-09 [Member] | AveXis, Inc. [Member]            
Significant Accounting Policies [Line Items]            
Interest income from licensing 0   0      
Results Without Adoption of Topic 606 | ASU 2014-09 [Member] | AveXis, Inc. [Member] | License [Member]            
Significant Accounting Policies [Line Items]            
License revenue $ 100,000   $ 180,000