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Significant Agreements - Schedule of License Revenue (Detail) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
License Agreement Revenue Recognition [Abstract]      
Up-front fees and option fees for commercial licenses $ 3,050 $ 5,900 $ 4,000
Maintenance fees for commercial licenses 910 635 385
Milestone fees   250  
Research and other license revenue 343 240 190
Licenses revenue including amounts from related parties $ 4,303 $ 7,025 $ 4,575