Selected Quarterly Financial Information (Unaudited)

12 Months Ended

Dec. 31, 2016

Quarterly Financial Information Disclosure [Abstract]

Selected Quarterly Financial Information (Unaudited)

15. Selected Quarterly Financial Information (Unaudited)

The following table contains quarterly financial information for the years ended December 31, 2016 and 2015. Management believes that the following information reflects all normal recurring adjustments necessary for a fair statement of the information for the periods presented. The operating results for any quarter are not necessarily indicative of results for any future period. Amounts in the following table are in thousands, except per share data.

	Quarters Ended
	March 31, 2016			June 30, 2016			September 30, 2016			December 31, 2016
Total revenues	$	393		$	2,375		$	125		$	1,696
Research and development expense	$	6,183		$	10,680		$	12,560		$	16,059
General and administrative expense	$	5,479		$	6,169		$	6,200		$	5,742
Total operating expenses	$	11,644		$	17,327		$	18,793		$	22,165
Net loss	$	(10,768	)	$	(14,437	)	$	(18,154	)	$	(19,608	)
Basic and diluted net loss per common share	$	(0.41	)	$	(0.55	)	$	(0.69	)	$	(0.74	)

	Quarters Ended
	March 31, 2015			June 30, 2015			September 30, 2015			December 31, 2015
Total revenues	$	644		$	1,363		$	1,140		$	4,441
Research and development expense	$	2,791		$	4,012		$	5,664		$	4,812
General and administrative expense	$	1,716		$	3,397		$	2,567		$	4,232
Total operating expenses	$	4,637		$	7,659		$	8,487		$	9,942
Net loss	$	(4,011	)	$	(6,290	)	$	(7,332	)	$	(5,178	)
Basic and diluted net loss per common share	$	(0.94	)	$	(3.24	)	$	(1.52	)	$	(0.20	)